SPON2

SPON2 (Spondin 2) is a Protein Coding gene. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include antigen binding and lipopolysaccharide binding. An important paralog of this gene is SPON1.

Full Name

Spondin 2

Function

Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity).
Binds bacterial lipopolysaccharide (LPS).

Biological Process

Biological Process cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to lipopolysaccharideIEA:Ensembl
Biological Process defense response to fungusIEA:Ensembl
Biological Process defense response to virusIEA:Ensembl
Biological Process induction of bacterial agglutinationIEA:Ensembl
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process mast cell mediated immunityIEA:Ensembl
Biological Process opsonizationIEA:Ensembl
Biological Process positive regulation of interleukin-6 productionIEA:Ensembl
Biological Process positive regulation of macrophage cytokine productionIEA:Ensembl
Biological Process positive regulation of tumor necrosis factor productionIEA:Ensembl

Cellular Location

Secreted, extracellular space, extracellular matrix