STARD10

STARD10 (StAR Related Lipid Transfer Domain Containing 10) is a Protein Coding gene. Diseases associated with STARD10 include Hereditary Myopathy With Early Respiratory Failure. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include lipid binding.May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.

Full Name

StAR Related Lipid Transfer Domain Containing 10

Function

May play metabolic roles in sperm maturation or fertilization (By similarity).
Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.

Biological Process

Lipid transport

Cellular Location

Cell projection, cilium, flagellum
Cytoplasm
Membrane
In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm (By similarity).
Mainly cytosolic.

PTM

Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association.