TAF6L

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq]

Full Name

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa

Function

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity).

Biological Process

Biological Process chromatin remodelingTAS:ProtInc1 Publication
Biological Process histone acetylationIC:ComplexPortal1 Publication
Biological Process histone H3 acetylationIDA:UniProtKB1 Publication
Biological Process monoubiquitinated histone deubiquitinationIDA:ComplexPortal1 Publication
Biological Process monoubiquitinated histone H2A deubiquitinationIDA:ComplexPortal1 Publication
Biological Process positive regulation of DNA-templated transcriptionIC:ComplexPortal1 Publication
Biological Process regulation of DNA repairIC:ComplexPortal1 Publication
Biological Process regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process regulation of RNA splicingIC:ComplexPortal1 Publication
Biological Process regulation of somatic stem cell population maintenanceISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IITAS:ProtInc1 Publication
Biological Process RNA polymerase II preinitiation complex assemblyIBA:GO_Central1 Publication

Cellular Location

Nucleus