TCF15

TCF15 is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding.

Full Name

Transcription Factor 15

Function

Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal. Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells. Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes.

Biological Process

Biological Process developmental processIBA:GO_Central1 Publication
Biological Process ear developmentIEA:Ensembl
Biological Process establishment of epithelial cell apical/basal polarityIEA:Ensembl
Biological Process mesenchymal to epithelial transitionIEA:Ensembl
Biological Process mesoderm developmentTAS:ProtInc1 Publication
Biological Process muscle organ morphogenesisIEA:Ensembl
Biological Process negative regulation of hematopoietic stem cell differentiationISS:UniProtKB
Biological Process neuromuscular process controlling postureIEA:Ensembl
Biological Process paraxial mesoderm developmentIEA:Ensembl
Biological Process positive regulation of stem cell differentiationISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Biological Process post-anal tail morphogenesisIEA:Ensembl
Biological Process regulation of extracellular matrix organizationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process respiratory system processIEA:Ensembl
Biological Process skeletal system morphogenesisIEA:Ensembl
Biological Process somitogenesisIEA:Ensembl
Biological Process stem cell population maintenanceISS:UniProtKB

Cellular Location

Nucleus