TFB2M

TFB2M (Transcription Factor B2, Mitochondrial) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Gene Expression. Gene Ontology (GO) annotations related to TFB2M include rRNA methyltransferase activity.

Full Name

transcription factor B2, mitochondrial

Function

S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603, PubMed:12068295, PubMed:20410300, PubMed:15526033).
In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603, PubMed:15526033).
Stimulates transcription independently of the methyltransferase activity (PubMed:12897151).

Biological Process

Biological Process mitochondrial transcriptionSource:GO_Central1 Publication
Biological Process regulation of DNA-templated transcriptionSource:InterPro
Biological Process rRNA methylationSource:GO_Central1 Publication
Biological Process transcription initiation at mitochondrial promoterSource:UniProtKB2 Publications

Cellular Location

Mitochondrion