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THEMIS

Themis is a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. Themis functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.

Full Name

Thymocyte Selection Associated

Function

Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.

Biological Process

Biological Process adaptive immune responseSource:UniProtKB-KW
Biological Process negative T cell selectionSource:UniProtKB
Biological Process positive T cell selectionSource:UniProtKB
Biological Process T cell receptor signaling pathwaySource:UniProtKB

Cellular Location

Cytoplasm
Nucleus

PTM

Phosphorylated on Tyr residues quickly after TCR stimulation.

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Anti-THEMIS antibodies

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Rat Anti-Themis Recombinant Antibody (CBYJT-2967) (CBMAB-T2214-YJ)

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Target: Themis

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBYJT-2967

Application*: WB, IS, MC

Rabbit Anti-THEMIS Recombinant Antibody (
7G7) (V2LY-0725-LY1133)

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Target: THEMIS

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 7G7

Application*: E, IH, IF, F

Rat Anti-Themis Recombinant Antibody (CBYJT-2966) (CBMAB-T2213-YJ)

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Target: Themis

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBYJT-2966

Application*: F

Rat Anti-Themis Recombinant Antibody (12K186) (CBMAB-T2212-YJ)

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Target: Themis

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: 12K186

Application*: F, WB

Mouse Anti-THEMIS Recombinant Antibody (CBYJT-2965) (CBMAB-T2211-YJ)

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Target: THEMIS

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: CBYJT-2965

Application*: WB

Mouse Anti-THEMIS Recombinant Antibody (CBYJT-2964) (CBMAB-T2210-YJ)

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Target: THEMIS

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Clone: CBYJT-2964

Application*: WB, IP, IF, E

Mouse Anti-THEMIS Recombinant Antibody (CBYJT-2961) (CBMAB-T2207-YJ)

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Target: THEMIS

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-2961

Application*: IS, MC

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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