Rat Anti-Themis Recombinant Antibody (CBYJT-2966) (CBMAB-T2213-YJ)

Name: Rat Anti-Themis Recombinant Antibody (CBYJT-2966)
SKU: CBMAB-T2213-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

CBYJT-2966

Application

Specificity

Mouse

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2, 0.1% Gelatin

Preservative

0.09% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Thymocyte Selection Associated

Introduction

Themis is a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. Themis functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.

Entrez Gene ID

210757

UniProt ID

Q8BGW0

Alternative Names

Gasp; Spot; Tsepa; thylex; E430004N04Rik

Function

Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.

Biological Process

Biological Process adaptive immune responseSource:UniProtKB-KW
Biological Process negative T cell selectionSource:UniProtKB
Biological Process positive T cell selectionSource:UniProtKB
Biological Process T cell receptor signaling pathwaySource:UniProtKB

Cellular Location

Cytoplasm
Nucleus

PTM

Phosphorylated on Tyr residues quickly after TCR stimulation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rabbit Anti-THEMIS Recombinant Antibody (
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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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