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TMEFF2

TMEFF2 is a member of the tomoregulin family of transmembrane proteins. TMEFF2 has been shown to play a role as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, TMEFF2 has been found to be hypermethylated in multiple cancer types.
Full Name
transmembrane protein with EGF-like and two follistatin-like domains 2
Function
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
Biological Process
Biological Process animal organ morphogenesisSource:GO_Central1 Publication
Biological Process cell migrationSource:GO_Central1 Publication
Biological Process negative regulation of cell migrationSource:MGI1 Publication
Biological Process negative regulation of integrin biosynthetic processSource:MGI1 Publication
Biological Process negative regulation of stress fiber assemblySource:MGI1 Publication
Biological Process substrate adhesion-dependent cell spreadingSource:GO_Central1 Publication
Biological Process tissue developmentSource:GO_Central1 Publication
Biological Process wound healing, spreading of cellsSource:MGI1 Publication
Cellular Location
Isoform 1
Membrane
Isoform 2
Membrane
Isoform 3
Secreted
Topology
Extracellular: 41-320
Helical: 321-341
Cytoplasmic: 342-374
PTM
N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.
A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17.
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Anti-TMEFF2 antibodies

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Mouse Anti-TMEFF2 Recombinant Antibody (1D12) (CBMAB-A9212-LY)

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Target: TMEFF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D12
Application*: WB, E
Datasheet SDS

Mouse Anti-TMEFF2 Recombinant Antibody (J4B6) (CBMAB-T2804-YJ)

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Target: TMEFF2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: J4B6
Application*: WB, E, IH, P
Datasheet SDS

Mouse Anti-TMEFF2 Recombinant Antibody (CBYJT-3479) (CBMAB-T2803-YJ)

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Target: TMEFF2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: CBYJT-3479
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-TMEFF2 Recombinant Antibody (CBYJT-3478) (CBMAB-T2802-YJ)

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Target: TMEFF2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3478
Application*: F, WB
Datasheet SDS

Mouse Anti-TMEFF2 Recombinant Antibody (CBYJT-3477) (CBMAB-T2801-YJ)

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Target: TMEFF2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3477
Application*: WB, IH
Datasheet SDS

Mouse Anti-TMEFF2 Recombinant Antibody (CBYJT-3476) (CBMAB-T2800-YJ)

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Target: TMEFF2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3476
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-TMEFF2 Recombinant Antibody (CBYJT-3475) (CBMAB-T2799-YJ)

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Target: TMEFF2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3475
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-TMEFF2 Recombinant Antibody (CBYJT-3474) (CBMAB-T2798-YJ)

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Target: TMEFF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3474
Application*: E, WB
Datasheet SDS

Mouse Anti-TMEFF2 Recombinant Antibody (CBYJT-3473) (CBMAB-T2797-YJ)

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Target: TMEFF2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3473
Application*: WB, IH
Datasheet SDS

Mouse Anti-TMEFF2 Recombinant Antibody (CBYJT-3472) (CBMAB-T2796-YJ)

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Target: TMEFF2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3472
Application*: WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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