TMEFF2

TMEFF2 is a member of the tomoregulin family of transmembrane proteins. TMEFF2 has been shown to play a role as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, TMEFF2 has been found to be hypermethylated in multiple cancer types.

transmembrane protein with EGF-like and two follistatin-like domains 2

May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.

Biological Process animal organ morphogenesisSource:GO_Central1 Publication
Biological Process cell migrationSource:GO_Central1 Publication
Biological Process negative regulation of cell migrationSource:MGI1 Publication
Biological Process negative regulation of integrin biosynthetic processSource:MGI1 Publication
Biological Process negative regulation of stress fiber assemblySource:MGI1 Publication
Biological Process substrate adhesion-dependent cell spreadingSource:GO_Central1 Publication
Biological Process tissue developmentSource:GO_Central1 Publication
Biological Process wound healing, spreading of cellsSource:MGI1 Publication

Isoform 1
Membrane
Isoform 2
Membrane
Isoform 3
Secreted

Extracellular: 41-320
Helical: 321-341
Cytoplasmic: 342-374

N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.
A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17.