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Mouse Anti-TMEFF2 Recombinant Antibody (1D12) (CBMAB-A9212-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1D12
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TMEFF2 (NP_057276.2, 201 a.a. ~ 292 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
transmembrane protein with EGF-like and two follistatin-like domains 2
Entrez Gene ID
23671
UniProt ID
Q9UIK5
Alternative Names
HPP1; TENB2; TPEF; TR
Function
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
Biological Process
Biological Process animal organ morphogenesisSource:GO_Central1 Publication
Biological Process cell migrationSource:GO_Central1 Publication
Biological Process negative regulation of cell migrationSource:MGI1 Publication
Biological Process negative regulation of integrin biosynthetic processSource:MGI1 Publication
Biological Process negative regulation of stress fiber assemblySource:MGI1 Publication
Biological Process substrate adhesion-dependent cell spreadingSource:GO_Central1 Publication
Biological Process tissue developmentSource:GO_Central1 Publication
Biological Process wound healing, spreading of cellsSource:MGI1 Publication
Cellular Location
Isoform 1
Membrane
Isoform 2
Membrane
Isoform 3
Secreted
Topology
Extracellular: 41-320
Helical: 321-341
Cytoplasmic: 342-374
PTM
N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.
A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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