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Mouse Anti-TMEFF2 Recombinant Antibody (CBYJT-3475) (CBMAB-T2799-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3475
Antibody Isotype
IgG2a
Application
FC, IF, WB

Basic Information

Immunogen
TMEFF2 antibody was raised in Mouse using full length human recombinant protein of human TMEFF2 produced in HEK293T cell as the immunogen
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
transmembrane protein with EGF-like and two follistatin-like domains 2
Introduction
TMEFF2 is a member of the tomoregulin family of transmembrane proteins. TMEFF2 has been shown to play a role as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, TMEFF2 has been found to be hypermethylated in multiple cancer types.
Entrez Gene ID
23671
UniProt ID
Q9UIK5
Alternative Names
Transmembrane Protein With EGF Like And Two Follistatin Like Domains 2; Transmembrane Protein With EGF-Like And Two Follistatin-Like Domains; Cancer/Testis Antigen Family 120, Member 2; Hyperplastic Polyposis Protein 1; Transmembrane Protein TENB2; TENB2; HPP1; TPEF
Function
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
Biological Process
Biological Process animal organ morphogenesisSource:GO_Central1 Publication
Biological Process cell migrationSource:GO_Central1 Publication
Biological Process negative regulation of cell migrationSource:MGI1 Publication
Biological Process negative regulation of integrin biosynthetic processSource:MGI1 Publication
Biological Process negative regulation of stress fiber assemblySource:MGI1 Publication
Biological Process substrate adhesion-dependent cell spreadingSource:GO_Central1 Publication
Biological Process tissue developmentSource:GO_Central1 Publication
Biological Process wound healing, spreading of cellsSource:MGI1 Publication
Cellular Location
Isoform 1
Membrane
Isoform 2
Membrane
Isoform 3
Secreted
Topology
Extracellular: 41-320
Helical: 321-341
Cytoplasmic: 342-374
PTM
N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.
A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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