Mouse Anti-TMEFF2 Recombinant Antibody (CBYJT-3479) (CBMAB-T2803-YJ)

Name: Mouse Anti-TMEFF2 Recombinant Antibody (CBYJT-3479)
SKU: CBMAB-T2803-YJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3479

Application

ELISA, IHC, WB

Immunogen

Recombinant human TMEFF2 (41-150aa) purified from E. coli. (NP_057276)

Specificity

Human, Mouse

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Preservative

0.09% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 41-150

More Infomation

Target

Full Name

transmembrane protein with EGF-like and two follistatin-like domains 2

Introduction

TMEFF2 is a member of the tomoregulin family of transmembrane proteins. TMEFF2 has been shown to play a role as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, TMEFF2 has been found to be hypermethylated in multiple cancer types.

Entrez Gene ID

Human	23671
Mouse	56363

UniProt ID

Human	Q9UIK5
Mouse	Q9QYM9

Alternative Names

Transmembrane Protein With EGF Like And Two Follistatin Like Domains 2; Transmembrane Protein With EGF-Like And Two Follistatin-Like Domains; Cancer/Testis Antigen Family 120, Member 2; Hyperplastic Polyposis Protein 1; Transmembrane Protein TENB2; TENB2; HPP1; TPEF

Function

May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.

Biological Process

Biological Process animal organ morphogenesisSource:GO_Central1 Publication
Biological Process cell migrationSource:GO_Central1 Publication
Biological Process negative regulation of cell migrationSource:MGI1 Publication
Biological Process negative regulation of integrin biosynthetic processSource:MGI1 Publication
Biological Process negative regulation of stress fiber assemblySource:MGI1 Publication
Biological Process substrate adhesion-dependent cell spreadingSource:GO_Central1 Publication
Biological Process tissue developmentSource:GO_Central1 Publication
Biological Process wound healing, spreading of cellsSource:MGI1 Publication

Cellular Location

Isoform 1
Membrane
Isoform 2
Membrane
Isoform 3
Secreted

Topology

Extracellular: 41-320
Helical: 321-341
Cytoplasmic: 342-374

PTM

N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.
A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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