TMPRSS15

TMPRSS15 is an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive.
Full Name
Transmembrane Protease, Serine 15
Function
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
Biological Process
Proteolysis
Cellular Location
Membrane
Involvement in disease
Enterokinase deficiency (ENTKD):
Life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.
Topology
Cytoplasmic: 2-18
Helical: 19-47
Extracellular: 48-1019
PTM
The chains are derived from a single precursor that is cleaved by a trypsin-like protease.
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Anti-TMPRSS15 antibodies

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Mouse Anti-TMPRSS15 Recombinant Antibody (3F8) (CBMAB-A7104-LY)

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Target: TMPRSS15
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F8
Application*: WB, E
Datasheet SDS

Mouse Anti-TMPRSS15 Recombinant Antibody (CBYJT-3558) (CBMAB-T2885-YJ)

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Target: TMPRSS15
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3558
Application*: E, WB
Datasheet SDS

Cattle Recombinant Enterokinase protein, His Tag (V2LY-0526-LY1186)

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Target: TMPRSS15
Expressed Host: Yeast
Sequence: Amino Acid: 801-1035
Tag: His Tag
Datasheet SDS

Mouse Anti-TMPRSS15 Recombinant Antibody (MM0259- 8S12) (CBMAB-E2343-FY)

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Target: TMPRSS15
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0259- 8S12
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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