TNFRSF10B
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Full Name
TNFRSF10B Gene(Protein Coding) TNF Receptor Superfamily Member 10b
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288).
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Biological Process
Biological Process activation of NF-kappaB-inducing kinase activitySource:UniProtKB2 Publications
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cell surface receptor signaling pathwaySource:ProtInc1 Publication
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process defense response to tumor cellSource:ARUK-UCL1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:UniProtKB1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressSource:UniProtKB1 Publication
Biological Process positive regulation of apoptotic processSource:GO_Central1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingSource:UniProtKB1 Publication
Biological Process regulation of apoptotic processSource:UniProtKB1 Publication
Biological Process response to endoplasmic reticulum stressSource:UniProtKB1 Publication
Biological Process TRAIL-activated apoptotic signaling pathwaySource:GO_Central1 Publication
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cell surface receptor signaling pathwaySource:ProtInc1 Publication
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process defense response to tumor cellSource:ARUK-UCL1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:UniProtKB1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressSource:UniProtKB1 Publication
Biological Process positive regulation of apoptotic processSource:GO_Central1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingSource:UniProtKB1 Publication
Biological Process regulation of apoptotic processSource:UniProtKB1 Publication
Biological Process response to endoplasmic reticulum stressSource:UniProtKB1 Publication
Biological Process TRAIL-activated apoptotic signaling pathwaySource:GO_Central1 Publication
Cellular Location
Membrane
Involvement in disease
Squamous cell carcinoma of the head and neck (HNSCC):
A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
Topology
Extracellular: 56-210
Helical: 211-231
Cytoplasmic: 232-440
Helical: 211-231
Cytoplasmic: 232-440
PTM
(Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3.
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Anti-TNFRSF10B antibodies
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CompareTarget: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3657
Application*: F, MC
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CAP651
Application*: ICC, WB
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CB465A
Application*: ELISA, WB, ICC
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBAb231
Application*: WB, IC
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 7C6
Application*: E, E
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7A12
Application*: E, E
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6B8
Application*: E, E
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5A11
Application*: E, E
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F9
Application*: E, E
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B9
Application*: E, E
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1C3
Application*: E, E
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E11
Application*: WB, E
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4516
Application*: F
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJC-4515
Application*: FN, IP
Target: Tnfrsf10b
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-3662
Application*: F
Target: Tnfrsf10b
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3661
Application*: WB, IH, FN
Target: Tnfrsf10b
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3660
Application*: IH, WB
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYJT-3659
Application*: IC, WB
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TR2.21
Application*: F, IH, WB
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HS201
Application*: F, IC, IP
Target: TNFRSF10B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3655
Application*: WB, IP, IF
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: B-D37
Application*: E, IP, F, FN
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3654
Application*: F, MC
Target: TNFRSF10B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3653
Application*: E, F
Target: TNFRSF10B
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 9K26
Application*: IH, WB
Target: TNFRSF10B
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: MD5-1
Application*: F, IH
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCD-516
Application*: F, IC, IF, IP, FN
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DR5-01-1
Application*: F
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DR5-01
Application*: F
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-K29
Application*: F
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 7F4-F8-G11
Application*: IC, IF, WB
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D6
Application*: E, IP, WB
Target: TNFRSF10B
Sensitivity: 0.0089 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates, Ascites, tissue homogenates or other biological fluids
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Tnfrsf10b
Sensitivity: 0.124 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: TNFRSF10B
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-177
Tag: His Tag
Target: TNFRSF10B
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-177
Tag: His & hFc Tag
Target: TNFRSF10B
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-182
Tag: His Tag
Target: TNFRSF10B
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-182
Tag: His Tag
Target: TNFRSF10B
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-182
Tag: His & AVI Tag
Target: TNFRSF10B
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-182
Tag: hFc Tag
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 20H9
Application*: E, WB, IC
Target: TNFRSF10B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4707
Application*: WB
Target: TNFRSF10B
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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