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TNFRSF10B

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

Full Name

TNFRSF10B Gene(Protein Coding) TNF Receptor Superfamily Member 10b

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288).
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Biological Process

Biological Process activation of NF-kappaB-inducing kinase activitySource:UniProtKB2 Publications
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cell surface receptor signaling pathwaySource:ProtInc1 Publication
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process defense response to tumor cellSource:ARUK-UCL1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:UniProtKB1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressSource:UniProtKB1 Publication
Biological Process positive regulation of apoptotic processSource:GO_Central1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingSource:UniProtKB1 Publication
Biological Process regulation of apoptotic processSource:UniProtKB1 Publication
Biological Process response to endoplasmic reticulum stressSource:UniProtKB1 Publication
Biological Process TRAIL-activated apoptotic signaling pathwaySource:GO_Central1 Publication

Cellular Location

Membrane

Involvement in disease

Squamous cell carcinoma of the head and neck (HNSCC):
A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.

Topology

Extracellular: 56-210
Helical: 211-231
Cytoplasmic: 232-440

PTM

(Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3.

Anti-TNFRSF10B antibodies

Mouse Anti-TNFRSF10B Recombinant Antibody (2D6) (CBMAB-D2293-YC)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2D6

Application*: E, IP, WB

Mouse Anti-TNFRSF10B Recombinant Antibody (7F4-F8-G11) (CBMAB-D2296-YC)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: 7F4-F8-G11

Application*: IC, IF, WB

Mouse Anti-TNFRSF10B Recombinant Antibody (B-K29) (CBMAB-D2297-YC)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: B-K29

Application*: F

Mouse Anti-TNFRSF10B Recombinant Antibody (DR5-01) (CBMAB-D2300-YC)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: DR5-01

Application*: F

Mouse Anti-TNFRSF10B Recombinant Antibody (DR5-01-1) (CBMAB-D2301-YC)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: DR5-01-1

Application*: F

Mouse Anti-TNFRSF10B Recombinant Antibody (CBYCD-516) (CBMAB-D2302-YC)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCD-516

Application*: F, IC, IF, IP, FN

Hamster Anti-TNFRSF10B Recombinant Antibody (MD5-1) (CBMAB-D2304-YC)

SDS

Target: TNFRSF10B

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: MD5-1

Application*: F, IH

Rat Anti-TNFRSF10B Recombinant Antibody (9K26) (CBMAB-D2305-YC)

SDS

Target: TNFRSF10B

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: 9K26

Application*: IH, WB

Mouse Anti-TNFRSF10B Recombinant Antibody (CBWJC-4516) (CBMAB-C5909WJ)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJC-4516

Application*: F

Hamster Anti-Tnfrsf10b Recombinant Antibody (CBYJT-3662) (CBMAB-T3031-YJ)

SDS

Target: Tnfrsf10b

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYJT-3662

Application*: F

Rat Anti-Tnfrsf10b Recombinant Antibody (CBYJT-3661) (CBMAB-T3030-YJ)

SDS

Target: Tnfrsf10b

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYJT-3661

Application*: WB, IH, FN

Rat Anti-Tnfrsf10b Recombinant Antibody (CBYJT-3660) (CBMAB-T3029-YJ)

SDS

Target: Tnfrsf10b

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYJT-3660

Application*: IH, WB

Mouse Anti-TNFRSF10B Recombinant Antibody (CBYJT-3659) (CBMAB-T3028-YJ)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBYJT-3659

Application*: IC, WB

Mouse Anti-TNFRSF10B Recombinant Antibody (CB465A) (CBMAB-CA465LY)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CB465A

Application*: ELISA, WB, ICC

Mouse Anti-TNFRSF10B Recombinant Antibody (TR2.21) (CBMAB-T3026-YJ)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: TR2.21

Application*: F, IH, WB

Rabbit Anti-TNFRSF10B Recombinant Antibody (CBYJT-3653) (CBMAB-T3016-YJ)

SDS

Target: TNFRSF10B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-3653

Application*: E, F

Mouse Anti-TNFRSF10B Recombinant Antibody (CBYJT-3654) (CBMAB-T3017-YJ)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-3654

Application*: F, MC

Mouse Anti-TNFRSF10B Recombinant Antibody (B-D37) (CBMAB-T3018-YJ)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: B-D37

Application*: E, IP, F, FN

Rabbit Anti-TNFRSF10B Recombinant Antibody (CBYJT-3655) (CBMAB-T3020-YJ)

SDS

Target: TNFRSF10B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-3655

Application*: WB, IP, IF

Mouse Anti-TNFRSF10B Recombinant Antibody (HS201) (CBMAB-T3024-YJ)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: HS201

Application*: F, IC, IP

Mouse Anti-TNFRSF10B Recombinant Antibody (CBYJT-3657) (CBMAB-T3025-YJ)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3657

Application*: F, MC

Mouse Anti-TNFRSF10B Recombinant Antibody (1E11) (CBMAB-A9250-LY)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1E11

Application*: WB, E

Mouse Anti-TNFRSF10B Recombinant Antibody (1C3) (CBMAB-A9251-LY)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1C3

Application*: E, E

Mouse Anti-TNFRSF10B Recombinant Antibody (2B9) (CBMAB-A9252-LY)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2B9

Application*: E, E

Mouse Anti-TNFRSF10B Recombinant Antibody (2F9) (CBMAB-A9254-LY)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2F9

Application*: E, E

Mouse Anti-TNFRSF10B Recombinant Antibody (CBWJC-4515) (CBMAB-C5908WJ)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJC-4515

Application*: FN, IP

Mouse Anti-TNFRSF10B Recombinant Antibody (5A11) (CBMAB-A9255-LY)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5A11

Application*: E, E

Mouse Anti-TNFRSF10B Recombinant Antibody (6B8) (CBMAB-A9256-LY)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6B8

Application*: E, E

Mouse Anti-TNFRSF10B Recombinant Antibody (7A12) (CBMAB-A9257-LY)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 7A12

Application*: E, E

Mouse Anti-TNFRSF10B Recombinant Antibody (7C6) (CBMAB-A9258-LY)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 7C6

Application*: E, E

Recombinant Mouse Anti-TNFRSF10B Antibody (CBAb231) (CBMAB-Ab231-LY)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBAb231

Application*: WB, IC

Mouse Anti-TNFRSF10B Recombinant Antibody (CAP651) (CBMAB-AP1945LY)

SDS

Target: TNFRSF10B

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CAP651

Application*: ICC, WB

TNFRSF10B Matched Antibody Pair (1216) (APMAB-1216LY)

SDS

Target: TNFRSF10B

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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