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Mouse Anti-TNFRSF10B Recombinant Antibody (CBT4707) (V2LY-0625-LY1152)


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Tested Data
Mouse Anti-TNFRSF10B Recombinant Antibody (CBT4707) (V2LY-0625-LY1152) in ELISA
Mouse Anti-TNFRSF10B Recombinant Antibody (CBT4707) (V2LY-0625-LY1152) in ELISA
Mouse Anti-TNFRSF10B Recombinant Antibody (CBT4707) (V2LY-0625-LY1152) in WB
Mouse Anti-TNFRSF10B Recombinant Antibody (CBT4707) (V2LY-0625-LY1152) in WB
Mouse Anti-TNFRSF10B Recombinant Antibody (CBT4707) (V2LY-0625-LY1152) in WB
Mouse Anti-TNFRSF10B Recombinant Antibody (CBT4707) (V2LY-0625-LY1152) in WB

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4707
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human TNFRSF10B (AA: extra 56-210) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TNFRSF10B Gene(Protein Coding) TNF Receptor Superfamily Member 10b
Entrez Gene ID
8795
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288).
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Biological Process
Biological Process activation of NF-kappaB-inducing kinase activitySource:UniProtKB2 Publications
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cell surface receptor signaling pathwaySource:ProtInc1 Publication
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process defense response to tumor cellSource:ARUK-UCL1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:UniProtKB1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressSource:UniProtKB1 Publication
Biological Process positive regulation of apoptotic processSource:GO_Central1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingSource:UniProtKB1 Publication
Biological Process regulation of apoptotic processSource:UniProtKB1 Publication
Biological Process response to endoplasmic reticulum stressSource:UniProtKB1 Publication
Biological Process TRAIL-activated apoptotic signaling pathwaySource:GO_Central1 Publication
Cellular Location
Membrane
Involvement in disease
Squamous cell carcinoma of the head and neck (HNSCC):
A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
Topology
Extracellular: 56-210
Helical: 211-231
Cytoplasmic: 232-440
PTM
(Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3.
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For research use only. Not intended for any clinical use.

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