Mouse Anti-TNFRSF10B Recombinant Antibody (CBYJT-3657) (CBMAB-T3025-YJ)

Name: Mouse Anti-TNFRSF10B Recombinant Antibody (CBYJT-3657)
SKU: CBMAB-T3025-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-3657

Application

FC, CyTOF

Immunogen

Human TRAIL-R2

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TNFRSF10B Gene(Protein Coding) TNF Receptor Superfamily Member 10b

Introduction

TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. It can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.

Entrez Gene ID

8795

UniProt ID

O14763

Alternative Names

TNF Receptor Superfamily Member 10b; Tumor Necrosis Factor Receptor Superfamily, Member 10b; TNF-Related Apoptosis-Inducing Ligand Receptor 2; Death Receptor 5; TRAIL-R2; TRAILR2; KILLER; TRICK2; ZTNFR9; DR5; P53-Regulated DNA Damage-Inducible Cell Death Receptor(Killer); Tumor Necrosis Factor Receptor Superfamily Member 10B; Tumor Necrosis Factor Receptor-Like Protein ZTNFR9

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288).
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Biological Process

Biological Process activation of NF-kappaB-inducing kinase activitySource:UniProtKB2 Publications
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cell surface receptor signaling pathwaySource:ProtInc1 Publication
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process defense response to tumor cellSource:ARUK-UCL1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:UniProtKB1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressSource:UniProtKB1 Publication
Biological Process positive regulation of apoptotic processSource:GO_Central1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingSource:UniProtKB1 Publication
Biological Process regulation of apoptotic processSource:UniProtKB1 Publication
Biological Process response to endoplasmic reticulum stressSource:UniProtKB1 Publication
Biological Process TRAIL-activated apoptotic signaling pathwaySource:GO_Central1 Publication

Cellular Location

Membrane

Involvement in disease

Squamous cell carcinoma of the head and neck (HNSCC):
A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.

Topology

Extracellular: 56-210
Helical: 211-231
Cytoplasmic: 232-440

PTM

(Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TNFRSF10B Matched Antibody Pair (1216) (CAT#: APMAB-1216LY)

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Isotype control

For research use only. Not intended for any clinical use.

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