TNFRSF18
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Full Name
TNFRSF18 Gene(Protein Coding) TNF Receptor Superfamily Member 18
Function
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of leukocyte migration Source:UniProtKB1 Publication
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of leukocyte migration Source:UniProtKB1 Publication
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Cell membrane
Isoform 2
Secreted
Topology
Extracellular: 26-162
Helical: 163-183
Cytoplasmic: 184-241
Helical: 163-183
Cytoplasmic: 184-241
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Anti-TNFRSF18 antibodies
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Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 110416
Application*: WB
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 108626
Application*: WB
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: A1433
Application*: FC, IP
Target: TNFRSF18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR068G
Application*: WB, IP, IHC, ICC, IHC-IF
Target: TNFRSF18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D5V7P
Application*: WB, IP, IH, P, IF (IC), F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBWJC-4525
Application*: F, E
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2443
Application*: E, F, WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBWJC-2442
Application*: F, E
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: T9P4G4
Application*: E, IH, WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: T10P2H9
Application*: E, IH, WB
Target: Tnfrsf18
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYJT-3778
Application*: F, C
Target: Tnfrsf18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3777
Application*: P, F
Target: Tnfrsf18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3776
Application*: E, F, WB
Target: Tnfrsf18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3775
Application*: WB, N
Target: Tnfrsf18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3774
Application*: P, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: CBYJT-3773
Application*: E, WB, IH
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3772
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYJT-3771
Application*: E, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYJT-3770
Application*: E, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3769
Application*: E, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3768
Application*: WB, IH
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3767
Application*: WB, F, N
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3766
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3765
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3764
Application*: E
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3763
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3762
Application*: E
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3761
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3760
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3759
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3173
Application*: ED, E F, N, WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-3172
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3319
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: CBLG1-2458
Application*: E, P, WB
Target: TNFRSF18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBLG1-2457
Application*: WB
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: MGIT07
Application*: E, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: MGIT02
Application*: E, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: MAB0860
Application*: B, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: AIT158D
Application*: E, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 9G8
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7R12
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 7C13
Application*: P, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 6D413
Application*: E, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6D412
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 6D39
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: 2H4
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L475
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L474
Application*: N, WB
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L472
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 11K8
Application*: E, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 11K7
Application*: E, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: YGITR765
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: YGIR765.4.16
Application*: FN, IH, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: T9P4G4/D7
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0313-7R12
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DT5D3
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 621
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: 11E203
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 10C362
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 108619
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYH-3313
Application*: F, IH, P
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2803
Application*: F
Target: TNFRSF18
Sensitivity: 0.154 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: TNFRSF18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-121
Tag: hFc Tag
Target: TNFRSF18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-153
Tag: Fc Tag
Target: TNFRSF18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 22-150
Tag: His Tag
Target: TNFRSF18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-161
Tag: His & AVI Tag
Target: TNFRSF18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-161
Tag: hFc Tag
Target: TNFRSF18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-161
Tag: His Tag
Compare
Target: TNFRSF18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-161
Tag: hFc & AVI Tag
Target: TNFRSF18
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-155
Tag: His Tag
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4444
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2323
Application*: IH, F
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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