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TNFRSF18

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Full Name
TNFRSF18 Gene(Protein Coding) TNF Receptor Superfamily Member 18
Function
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of leukocyte migration Source:UniProtKB1 Publication
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Topology
Extracellular: 26-162
Helical: 163-183
Cytoplasmic: 184-241

Anti-TNFRSF18 antibodies

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Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3769
Application*: E, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3768
Application*: WB, IH
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3767
Application*: WB, F, N
Target: Tnfrsf18
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYJT-3778
Application*: F, C
Target: Tnfrsf18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3777
Application*: P, F
Target: Tnfrsf18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3776
Application*: E, F, WB
Target: Tnfrsf18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3775
Application*: WB, N
Target: Tnfrsf18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3774
Application*: P, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: CBYJT-3773
Application*: E, WB, IH
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3772
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYJT-3771
Application*: E, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYJT-3770
Application*: E, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: MGIT02
Application*: E, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: MAB0860
Application*: B, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: AIT158D
Application*: E, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3766
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3765
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3764
Application*: E
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3763
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3762
Application*: E
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3761
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3760
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3759
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBWJC-4525
Application*: F, E
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2443
Application*: E, F, WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBWJC-2442
Application*: F, E
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3173
Application*: ED, E F, N, WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-3172
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3319
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYH-3313
Application*: F, IH, P
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2803
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: CBLG1-2458
Application*: E, P, WB
Target: TNFRSF18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBLG1-2457
Application*: WB
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: MGIT07
Application*: E, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 9G8
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7R12
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 108619
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 108626
Application*: WB
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 10C362
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 110416
Application*: WB
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: 11E203
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 621
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DT5D3
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0313-7R12
Application*: WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: T9P4G4/D7
Application*: WB
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: YGIR765.4.16
Application*: FN, IH, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: YGITR765
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 11K7
Application*: E, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 11K8
Application*: E, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L472
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L474
Application*: N, WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L475
Application*: F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: 2H4
Application*: WB
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 6D39
Application*: WB
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6D412
Application*: F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 6D413
Application*: E, F
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: T10P2H9
Application*: E, IH, WB
Target: TNFRSF18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: T9P4G4
Application*: E, IH, WB
Target: TNFRSF18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D5V7P
Application*: WB, IP, IH, P, IF (IC), F
Target: TNFRSF18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR068G
Application*: WB, IP, IHC, ICC, IHC-IF
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 7C13
Application*: P, F
Target: TNFRSF18
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: A1433
Application*: FC, IP
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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