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Mouse Anti-TNFRSF18 Recombinant Antibody (CBT4444) (V2LY-0625-LY1109)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4444
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human GITR (AA: 184-241) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TNFRSF18 Gene(Protein Coding) TNF Receptor Superfamily Member 18
Entrez Gene ID
8784
Function
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of leukocyte migration Source:UniProtKB1 Publication
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Topology
Extracellular: 26-162
Helical: 163-183
Cytoplasmic: 184-241
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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