Trpc4

Trpc4 forms a receptor regulated cation channel and mediates calcium transport in response to histamine H1 receptor activation.

Transient Receptor Potential Cation Channel, Subfamily C, Member 4

Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.

Biological Process calcium ion import Source:BHF-UCL1 Publication
Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process calcium ion transport Source:ProtInc1 Publication
Biological Process gamma-aminobutyric acid secretion Source:Ensembl
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process oligodendrocyte differentiation Source:Ensembl
Biological Process regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication

Membrane
Cell membrane
Enhanced insertion into the cell membrane after activation of the EGF receptor.

Cytoplasmic: 1-329
Helical: 330-350
Extracellular: 351-362
Helical: 363-383
Cytoplasmic: 384-436
Helical: 437-457
Extracellular: 458-469
Helical: 470-490
Cytoplasmic: 491-511
Helical: 512-532
Extracellular: 533-599
Helical: 600-620
Cytoplasmic: 621-977

Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with SLC9A3R1/NHERF.