Trpc4

Trpc4 forms a receptor regulated cation channel and mediates calcium transport in response to histamine H1 receptor activation.

Full Name

Transient Receptor Potential Cation Channel, Subfamily C, Member 4

Function

Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.

Biological Process

Biological Process calcium ion import Source:BHF-UCL1 Publication
Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process calcium ion transport Source:ProtInc1 Publication
Biological Process gamma-aminobutyric acid secretion Source:Ensembl
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process oligodendrocyte differentiation Source:Ensembl
Biological Process regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication

Cellular Location

Membrane
Cell membrane
Enhanced insertion into the cell membrane after activation of the EGF receptor.

Topology

Cytoplasmic: 1-329
Helical: 330-350
Extracellular: 351-362
Helical: 363-383
Cytoplasmic: 384-436
Helical: 437-457
Extracellular: 458-469
Helical: 470-490
Cytoplasmic: 491-511
Helical: 512-532
Extracellular: 533-599
Helical: 600-620
Cytoplasmic: 621-977

PTM

Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with SLC9A3R1/NHERF.