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Mouse Anti-Trpc4 Recombinant Antibody (CBYJT-4900) (CBMAB-T4446-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Trpc4 (Transient Receptor Potential Cation Channel, Subfamily C, Member 4). The antibody can be used for immunoassay techniques, such as ICC, IP, WB.
See all Trpc4 antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Human, Mouse, Rabbit
Clone
CBYJT-4900
Antibody Isotype
IgG2b
Application
ICC, IP, WB

Basic Information

Immunogen
Synthetic peptide aas 930-947 of rat TrpC4 (also known as short transient receptor potential channel 4, Trp4, capacitative calcium entry channel 1 and CCE1, accession number O35119)
Specificity
Rat, Human, Mouse, Rabbit
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 930-947

Target

Full Name
Transient Receptor Potential Cation Channel, Subfamily C, Member 4
Introduction
Trpc4 forms a receptor regulated cation channel and mediates calcium transport in response to histamine H1 receptor activation.
Entrez Gene ID
Human7223
Mouse22066
Rat84494
Rabbit100353818
UniProt ID
HumanQ9UBN4
MouseQ9QUQ5
RatO35119
RabbitG1T2X5
Alternative Names
Trp4; Trrp4
Function
Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
Biological Process
Biological Process calcium ion import Source:BHF-UCL1 Publication
Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process calcium ion transport Source:ProtInc1 Publication
Biological Process gamma-aminobutyric acid secretion Source:Ensembl
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process oligodendrocyte differentiation Source:Ensembl
Biological Process regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Cellular Location
Membrane
Cell membrane
Enhanced insertion into the cell membrane after activation of the EGF receptor.
Topology
Cytoplasmic: 1-329
Helical: 330-350
Extracellular: 351-362
Helical: 363-383
Cytoplasmic: 384-436
Helical: 437-457
Extracellular: 458-469
Helical: 470-490
Cytoplasmic: 491-511
Helical: 512-532
Extracellular: 533-599
Helical: 600-620
Cytoplasmic: 621-977
PTM
Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with SLC9A3R1/NHERF.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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