TRPM4

TRPM4 is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium.

Transient Receptor Potential Cation Channel Subfamily M Member 4

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723, PubMed:30528822).
While it is activated by increase in intracellular Ca2+, it is impermeable to it (PubMed:12015988).
Mediates transport of monovalent cations (Na+> K+> Cs+> Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822).

Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process calcium-mediated signaling Source:BHF-UCL1 Publication
Biological Process cation transmembrane transport Source:GO_Central1 Publication
Biological Process cellular response to ATP Source:Ensembl
Biological Process dendritic cell chemotaxis Source:UniProtKB
Biological Process inorganic cation transmembrane transport Source:UniProtKB1 Publication
Biological Process membrane depolarization during AV node cell action potential Source:BHF-UCL1 Publication
Biological Process membrane depolarization during bundle of His cell action potential Source:BHF-UCL1 Publication
Biological Process membrane depolarization during Purkinje myocyte cell action potential Source:BHF-UCL1 Publication
Biological Process negative regulation of bone mineralization Source:BHF-UCL
Biological Process negative regulation of osteoblast differentiation Source:BHF-UCL
Biological Process positive regulation of adipose tissue development Source:BHF-UCL
Biological Process positive regulation of atrial cardiac muscle cell action potential Source:BHF-UCL
Biological Process positive regulation of canonical Wnt signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of cytosolic calcium ion concentration Source:BHF-UCL
Biological Process positive regulation of fat cell differentiation Source:BHF-UCL
Biological Process positive regulation of heart rate Source:BHF-UCL
Biological Process positive regulation of insulin secretion involved in cellular response to glucose stimulus Source:BHF-UCL
Biological Process positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization Source:BHF-UCL
Biological Process positive regulation of vasoconstriction Source:BHF-UCL
Biological Process protein homotetramerization Source:UniProtKB2 Publications
Biological Process protein sumoylation Source:UniProtKB1 Publication
Biological Process regulation of heart rate by cardiac conduction Source:BHF-UCL1 Publication
Biological Process regulation of T cell cytokine production Source:UniProtKB1 Publication
Biological Process regulation of ventricular cardiac muscle cell action potential Source:BHF-UCL1 Publication
Biological Process sodium ion import across plasma membrane Source:BHF-UCL1 Publication
Biological Process vasoconstriction Source:InterPro

Isoform 1
Cell membrane
Endoplasmic reticulum
Golgi apparatus
Isoform 2
Cell membrane
Endoplasmic reticulum
Golgi apparatus

Progressive familial heart block 1B (PFHB1B):
A cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death.
Erythrokeratodermia variabilis et progressiva 6 (EKVP6):
A form of erythrokeratodermia variabilis et progressiva, a genodermatosis characterized by the coexistence of two independent skin lesions: transient erythema and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases. EKVP6 inheritance is autosomal dominant.

Cytoplasmic: 1-782
Helical: 783-803
Extracellular: 804-814
Helical: 815-835
Cytoplasmic: 836-863
Helical: 864-884
Extracellular: 885-886
Helical: 887-910
Cytoplasmic: 911-930
Helical: 931-951
Extracellular: 952-963
Pore-forming: 964-984
Extracellular: 985-1019
Helical: 1020-1040
Cytoplasmic: 1041-1214

Phosphorylation by PKC leads to increase the sensitivity to Ca2+.
Sumoylated. Desumoylated by SENP1.