UBA7

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]
Full Name
Ubiquitin Like Modifier Activating Enzyme 7
Function
Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.
Biological Process
Biological Process cellular response to DNA damage stimulus Source:GO_Central1 Publication
Biological Process ISG15-protein conjugation Source:HGNC-UCL1 Publication
Biological Process modification-dependent protein catabolic process Source:Ensembl
Biological Process protein modification by small protein conjugation Source:GO_Central1 Publication
Biological Process protein modification process Source:HGNC-UCL1 Publication
Cellular Location
cytoplasm
cytosol
nucleoplasm
nucleus
PTM
ISGylated.
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Anti-UBA7 antibodies

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Mouse Anti-UBA7 Recombinant Antibody (5B10) (CBMAB-AO1055LY)

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Target: UBA7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B10
Application*: WB
Datasheet SDS

Human Recombinant UBA7, Active protein, GST Tag (V2LY-0526-LY7477)

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Target: UBA7
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
Datasheet SDS

Mouse Anti-UBA7 Recombinant Antibody (CBT1265) (V2LY-0625-LY2891)

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Target: UBA7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1265
Application*: WB, E
Datasheet SDS

Mouse Anti-UBA7 Recombinant Antibody (CBYY-I0994) (CBMAB-I2162-YY)

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Target: UBA7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0994
Application*: WB, E
Datasheet SDS

Rabbit Anti-UBA7 Recombinant Antibody (CBFYU-037) (CBMAB-U0037-FY)

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Target: UBA7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBFYU-037
Application*: WB
Datasheet SDS

Mouse Anti-UBA7 Recombinant Antibody (CBFYU-036) (CBMAB-U0036-FY)

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Target: UBA7
Host: Mouse
Specificity: Human
Clone: CBFYU-036
Application*: WB, IC, P, C, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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