UBE2D1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. [provided by RefSeq]
Full Name
UBE2D1
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338).
In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386).
Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941).
Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044).
Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044).
Essential for viral activation of IRF3 (PubMed:19854139).
Mediates polyubiquitination of CYP3A4 (PubMed:19103148).
Biological Process
Biological Process negative regulation of BMP signaling pathway Source:Reactome
Biological Process negative regulation of transcription by RNA polymerase II Source:Reactome
Biological Process positive regulation of protein polyubiquitination Source:Ensembl
Biological Process positive regulation of protein ubiquitination Source:UniProtKB1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
PTM
Autoubiquitinated in vitro.
View more

Anti-UBE2D1 antibodies

+ Filters
Loading...

Mouse Anti-UBE2D1 Recombinant Antibody (2C6) (CBMAB-A9704-LY)

Go to compareCompare
Target: UBE2D1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2C6
Application*: WB, E
Datasheet SDS

Mouse Anti-UBE2D1 Antibody (14E5) (CBMAB-1734CQ)

Go to compareCompare
Target: UBE2D1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14E5
Application*: E, M
Datasheet SDS

Human Recombinant UBE2D1 protein, His Tag (V2LY-0526-LY7485)

Go to compareCompare
Target: UBE2D1
Expressed Host: E. coli
Sequence: Amino Acid: 2-147
Tag: His Tag
Datasheet SDS

Human Recombinant UBE2D1, Active protein, His Tag (V2LY-0526-LY7484)

Go to compareCompare
Target: UBE2D1
Expressed Host: E. coli
Sequence: Amino Acid: Full Length
Tag: His Tag
Datasheet SDS

Mouse Anti-UBE2D1 Recombinant Antibody (CBFYU-082) (CBMAB-U0082-FY)

Go to compareCompare
Target: UBE2D1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYU-082
Application*: WB
Datasheet SDS

Mouse Anti-UBE2D1 Recombinant Antibody (CBFYU-081) (CBMAB-U0081-FY)

Go to compareCompare
Target: UBE2D1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-081
Application*: WB
Datasheet SDS

Mouse Anti-UBE2D1 Recombinant Antibody (CBFYU-080) (CBMAB-U0080-FY)

Go to compareCompare
Target: UBE2D1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYU-080
Application*: F
Datasheet SDS

Mouse Anti-UBE2D1 Recombinant Antibody (CBFYU-079) (CBMAB-U0079-FY)

Go to compareCompare
Target: UBE2D1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYU-079
Application*: E, WB, P
Datasheet SDS

Mouse Anti-UBE2D1 Recombinant Antibody (CBFYU-078) (CBMAB-U0078-FY)

Go to compareCompare
Target: UBE2D1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYU-078
Application*: E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.