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Mouse Anti-UBE2D1 Antibody (14E5) (CBMAB-1734CQ)

This product is a mouse antibody that recognizes UBE2D1. The antibody 14E5 can be used for immunoassay techniques such as: ELISA, MA.
See all UBE2D1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
14E5
Antibody Isotype
IgG1
Application
ELISA, MA

Basic Information

Immunogen
E. coli expressed recombinant full length protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
UBE2D1
Introduction
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. Diseases associated with UBE2D1 include Hemochromatosis and Hypoxia. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Ovarian tumor domain proteases.
Entrez Gene ID
7321
UniProt ID
P51668
Alternative Names
SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338).
In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386).
Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941).
Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044).
Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044).
Essential for viral activation of IRF3 (PubMed:19854139).
Mediates polyubiquitination of CYP3A4 (PubMed:19103148).
Biological Process
Biological Process negative regulation of BMP signaling pathway Source:Reactome
Biological Process negative regulation of transcription by RNA polymerase II Source:Reactome
Biological Process positive regulation of protein polyubiquitination Source:Ensembl
Biological Process positive regulation of protein ubiquitination Source:UniProtKB1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
PTM
Autoubiquitinated in vitro.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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