WNT2

WNT2 is a protein-coding gene which is a member of the WNT gene family. Diseases associated with WNT2 include Autism and Colorectal Cancer. Gene Ontology (GO) annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT2B.

Wnt family member 2

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874).
Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).

Biological Process atrial cardiac muscle tissue morphogenesis Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:UniProtKB1 Publication
Biological Process canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source:ParkinsonsUK-UCL1 Publication
Biological Process cardiac epithelial to mesenchymal transition Source:Ensembl
Biological Process cardiac muscle cell proliferation Source:Ensembl
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cell proliferation in midbrain Source:ParkinsonsUK-UCL1 Publication
Biological Process cell-cell signaling Source:BHF-UCL1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process cellular response to transforming growth factor beta stimulus Source:UniProtKB1 Publication
Biological Process epithelial cell proliferation involved in lung morphogenesis Source:Ensembl
Biological Process iris morphogenesis Source:BHF-UCLBy Similarity
Biological Process labyrinthine layer blood vessel development Source:Ensembl
Biological Process lens development in camera-type eye Source:BHF-UCLBy Similarity
Biological Process lung induction Source:Ensembl
Biological Process mammary gland epithelium development Source:UniProtKB1 Publication
Biological Process mesenchymal cell proliferation Source:Ensembl
Biological Process midbrain dopaminergic neuron differentiation Source:ParkinsonsUK-UCL1 Publication
Biological Process neurogenesis Source:ParkinsonsUK-UCL1 Publication
Biological Process neuron differentiation Source:UniProtKB
Biological Process positive regulation of cardiac muscle cell proliferation Source:Ensembl
Biological Process positive regulation of cell population proliferation Source:BHF-UCL1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:BHF-UCL1 Publication
Biological Process positive regulation of endothelial cell proliferation Source:Ensembl
Biological Process positive regulation of epithelial cell proliferation involved in lung morphogenesis Source:Ensembl
Biological Process positive regulation of fibroblast proliferation Source:BHF-UCL1 Publication
Biological Process positive regulation of mesenchymal cell proliferation Source:Ensembl
Biological Process positive regulation of neurogenesis Source:Ensembl
Biological Process positive regulation of transcription by RNA polymerase II Source:ParkinsonsUK-UCL1 Publication

Secreted, extracellular space, extracellular matrix
Secreted

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.