ZFAND5
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
Full Name
zinc finger, AN1-type domain 5
Function
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
Biological Process
Biological Process face development Source:Ensembl
Biological Process fibroblast migration Source:Ensembl
Biological Process in utero embryonic development Source:Ensembl
Biological Process platelet-derived growth factor receptor signaling pathway Source:Ensembl
Biological Process respiratory system process Source:Ensembl
Biological Process skeletal system morphogenesis Source:Ensembl
Biological Process smooth muscle tissue development Source:Ensembl
Biological Process vasculature development Source:Ensembl
Biological Process fibroblast migration Source:Ensembl
Biological Process in utero embryonic development Source:Ensembl
Biological Process platelet-derived growth factor receptor signaling pathway Source:Ensembl
Biological Process respiratory system process Source:Ensembl
Biological Process skeletal system morphogenesis Source:Ensembl
Biological Process smooth muscle tissue development Source:Ensembl
Biological Process vasculature development Source:Ensembl
Cellular Location
Cytoplasm
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Anti-ZFAND5 antibodies
+ Filters
Target: ZFAND5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F4
Application*: WB
Target: ZFAND5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9F2
Application*: P, WB
Target: ZFAND5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5B8
Application*: WB
Target: ZFAND5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5A9
Application*: WB
Target: ZFAND5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D8
Application*: P, WB
Target: ZFAND5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5H8
Application*: P, WB
Target: ZFAND5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A2
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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