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ZFAND5

Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

Full Name

zinc finger, AN1-type domain 5

Function

Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

Biological Process

Biological Process face development Source:Ensembl
Biological Process fibroblast migration Source:Ensembl
Biological Process in utero embryonic development Source:Ensembl
Biological Process platelet-derived growth factor receptor signaling pathway Source:Ensembl
Biological Process respiratory system process Source:Ensembl
Biological Process skeletal system morphogenesis Source:Ensembl
Biological Process smooth muscle tissue development Source:Ensembl
Biological Process vasculature development Source:Ensembl

Cellular Location

Cytoplasm

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Anti-ZFAND5 antibodies

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Mouse Anti-ZFAND5 Recombinant Antibody (2F4) (CBMAB-Z0195-WJ)

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Target: ZFAND5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2F4

Application*: WB

Mouse Anti-ZFAND5 Recombinant Antibody (9F2) (CBMAB-Z0194-WJ)

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Target: ZFAND5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 9F2

Application*: P, WB

Mouse Anti-ZFAND5 Recombinant Antibody (5B8) (CBMAB-Z0193-WJ)

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Target: ZFAND5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5B8

Application*: WB

Mouse Anti-ZFAND5 Recombinant Antibody (5A9) (CBMAB-Z0192-WJ)

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Target: ZFAND5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5A9

Application*: WB

Mouse Anti-ZFAND5 Recombinant Antibody (1D8) (CBMAB-Z0191-WJ)

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Target: ZFAND5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1D8

Application*: P, WB

Mouse Anti-ZFAND5 Recombinant Antibody (5H8) (CBMAB-Z0190-WJ)

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Target: ZFAND5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5H8

Application*: P, WB

Mouse Anti-ZFAND5 Recombinant Antibody (2A2) (CBMAB-Z0189-WJ)

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Target: ZFAND5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2A2

Application*: WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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