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Mouse Anti-DIDO1 Recombinant Antibody (3B1) (V2LY-0425-LY338)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B1
Antibody Isotype
IgG1, κ
Application
ELISA, WB, IF

Basic Information

Immunogen
Partial recombinant corresponding to a.a.321-420 from human DIDO1.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Death Inducer-Obliterator 1
Entrez Gene ID
11083
UniProt ID
Q9BTC0
Function
Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity).

Tumor suppressor. Required for early embryonic stem cell development.

Isoform 2:
Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.
Biological Process
Apoptotic signaling pathway Source: Ensembl
Transcription, DNA-templated Source: InterPro
Cellular Location
Cytoplasm; Spindle; Nucleus. Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis.
More Infomation

Cao, H., Wang, L., Geng, C., Yang, M., Mao, W., Yang, L., ... & Shen, Z. (2022). In leukemia, knock-down of the death inducer-obliterator gene would inhibit the proliferation of endothelial cells by inhibiting the expression of CDK6 and CCND1. PeerJ, 10, e12832.

Zhang, Y., Jiang, J., Zhang, J., Shen, H., Wang, M., Guo, Z., ... & Zhang, X. (2021). CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability. Molecular cancer, 20(1), 1-17.

Hiwasa, T., Wang, H., Goto, K. I., Mine, S., Machida, T., Kobayashi, E., ... & Iwadate, Y. (2021). Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke. BMC medicine, 19(1), 1-25.

Rosales, R., Viettri, M., Ding, S., Greenberg, H. B., & Ludert, J. (2021). The dengue virus non-structural protein 1 (NS1) interacts with the putative epigenetic regulator DIDO1 to promote flavivirus replication. bioRxiv.

Li, J., Wang, A. S., Wang, S., Wang, C. Y., Xue, S., Li, W. Y., ... & Shan, Y. X. (2020). Death-inducer obliterator 1 (DIDO1) silencing suppresses growth of bladder cancer cells through decreasing SAPK/JNK signaling cascades. Neoplasma, 67(5), 1074-1084.

Forghanifard, M. M., Naeimi Khorasanizadeh, P., Abbaszadegan, M. R., Javdani Mallak, A., & Moghbeli, M. (2020). Role of DIDO1 in progression of esophageal squamous cell carcinoma. Journal of Gastrointestinal Cancer, 51(1), 83-87.

Xiao, J., Zhang, R., Peng, J., & Yang, Z. (2020). BAP1 maintains chromosome stability by stabilizing DIDO1 in renal cell carcinoma. American journal of cancer research, 10(5), 1455.

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For research use only. Not intended for any clinical use.

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