Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-DIDO1 Recombinant Antibody (CBYCD-278) (V2LY-0425-LY337)


See all DIDO1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYCD-278
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 315-614 of mouse Dio-1.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Death Inducer-Obliterator 1
Entrez Gene ID
Human11083
Mouse23856
UniProt ID
HumanQ9BTC0
MouseQ8C9B9
Function
Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity).

Tumor suppressor. Required for early embryonic stem cell development.

Isoform 2:
Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.
Biological Process
Apoptotic signaling pathway Source: Ensembl
Transcription, DNA-templated Source: InterPro
Cellular Location
Cytoplasm; Spindle; Nucleus. Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis.
More Infomation

Cao, H., Wang, L., Geng, C., Yang, M., Mao, W., Yang, L., ... & Shen, Z. (2022). In leukemia, knock-down of the death inducer-obliterator gene would inhibit the proliferation of endothelial cells by inhibiting the expression of CDK6 and CCND1. PeerJ, 10, e12832.

Zhang, Y., Jiang, J., Zhang, J., Shen, H., Wang, M., Guo, Z., ... & Zhang, X. (2021). CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability. Molecular cancer, 20(1), 1-17.

Hiwasa, T., Wang, H., Goto, K. I., Mine, S., Machida, T., Kobayashi, E., ... & Iwadate, Y. (2021). Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke. BMC medicine, 19(1), 1-25.

Rosales, R., Viettri, M., Ding, S., Greenberg, H. B., & Ludert, J. (2021). The dengue virus non-structural protein 1 (NS1) interacts with the putative epigenetic regulator DIDO1 to promote flavivirus replication. bioRxiv.

Li, J., Wang, A. S., Wang, S., Wang, C. Y., Xue, S., Li, W. Y., ... & Shan, Y. X. (2020). Death-inducer obliterator 1 (DIDO1) silencing suppresses growth of bladder cancer cells through decreasing SAPK/JNK signaling cascades. Neoplasma, 67(5), 1074-1084.

Forghanifard, M. M., Naeimi Khorasanizadeh, P., Abbaszadegan, M. R., Javdani Mallak, A., & Moghbeli, M. (2020). Role of DIDO1 in progression of esophageal squamous cell carcinoma. Journal of Gastrointestinal Cancer, 51(1), 83-87.

Xiao, J., Zhang, R., Peng, J., & Yang, Z. (2020). BAP1 maintains chromosome stability by stabilizing DIDO1 in renal cell carcinoma. American journal of cancer research, 10(5), 1455.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-DIDO1 Recombinant Antibody (CBYCD-278)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry