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DIDO1

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]
Full Name
Death Inducer-Obliterator 1
Function
Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity).

Tumor suppressor. Required for early embryonic stem cell development.

Isoform 2:
Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.
Biological Process
Apoptotic signaling pathway Source: Ensembl
Transcription, DNA-templated Source: InterPro
Cellular Location
Cytoplasm; Spindle; Nucleus. Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis.
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Anti-DIDO1 antibodies

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Mouse Anti-DIDO1 Recombinant Antibody (3B1) (V2LY-0425-LY338)

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Target: DIDO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B1
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-DIDO1 Recombinant Antibody (CBYCD-278) (V2LY-0425-LY337)

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Target: DIDO1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYCD-278
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DIDO1 Recombinant Antibody (CBYCD-277) (V2LY-0425-LY336)

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Target: DIDO1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Mouse, Rat
Clone: CBYCD-277
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DIDO1 Recombinant Antibody (EG963) (CBMAB-EN1142-LY)

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Target: DIDO1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: EG963
Application*: WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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