DIDO1

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]

Death Inducer-Obliterator 1

Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity).

Tumor suppressor. Required for early embryonic stem cell development.

Isoform 2:
Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.

Apoptotic signaling pathway Source: Ensembl
Transcription, DNA-templated Source: InterPro

Cytoplasm; Spindle; Nucleus. Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis.