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Rabbit Anti-DIDO1 Recombinant Antibody (EG963) (CBMAB-EN1142-LY)

The product is antibody recognizes DIDO1. The antibody EG963 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all DIDO1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG963
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human DIDO1.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Death Inducer-Obliterator 1
Introduction
Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human11083
Mouse23856
UniProt ID
HumanQ9BTC0
MouseQ8C9B9
Alternative Names
Death Inducer-Obliterator 1; Death-Associated Transcription Factor 1; C20orf158; DATF-1; DATF1; DIO-1; Death Associated Transcription Factor 1; Chromosome 20 Open Reading Frame 158; Death-Inducer Obliterator 1;
Function
Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity).

Tumor suppressor. Required for early embryonic stem cell development.

Isoform 2:
Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.
Biological Process
Apoptotic signaling pathway Source: Ensembl
Transcription, DNA-templated Source: InterPro
Cellular Location
Cytoplasm; Spindle; Nucleus. Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis.

Cao, H., Wang, L., Geng, C., Yang, M., Mao, W., Yang, L., ... & Shen, Z. (2022). In leukemia, knock-down of the death inducer-obliterator gene would inhibit the proliferation of endothelial cells by inhibiting the expression of CDK6 and CCND1. PeerJ, 10, e12832.

Zhang, Y., Jiang, J., Zhang, J., Shen, H., Wang, M., Guo, Z., ... & Zhang, X. (2021). CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability. Molecular cancer, 20(1), 1-17.

Hiwasa, T., Wang, H., Goto, K. I., Mine, S., Machida, T., Kobayashi, E., ... & Iwadate, Y. (2021). Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke. BMC medicine, 19(1), 1-25.

Rosales, R., Viettri, M., Ding, S., Greenberg, H. B., & Ludert, J. (2021). The dengue virus non-structural protein 1 (NS1) interacts with the putative epigenetic regulator DIDO1 to promote flavivirus replication. bioRxiv.

Li, J., Wang, A. S., Wang, S., Wang, C. Y., Xue, S., Li, W. Y., ... & Shan, Y. X. (2020). Death-inducer obliterator 1 (DIDO1) silencing suppresses growth of bladder cancer cells through decreasing SAPK/JNK signaling cascades. Neoplasma, 67(5), 1074-1084.

Forghanifard, M. M., Naeimi Khorasanizadeh, P., Abbaszadegan, M. R., Javdani Mallak, A., & Moghbeli, M. (2020). Role of DIDO1 in progression of esophageal squamous cell carcinoma. Journal of Gastrointestinal Cancer, 51(1), 83-87.

Xiao, J., Zhang, R., Peng, J., & Yang, Z. (2020). BAP1 maintains chromosome stability by stabilizing DIDO1 in renal cell carcinoma. American journal of cancer research, 10(5), 1455.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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