Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-EFEMP1 Recombinant Antibody (CBXF-0123) (V2LY-0425-LY1480)


See all EFEMP1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0123
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
Recombinant protein Fibulin 3 (aa26-213).
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB0.01-2 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Glycerol & PBS
Preservative
Sodium Azide
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
2202
UniProt ID
Q12805
Research Area
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
Biological Process
Camera-type eye development Source: UniProtKB
Embryonic eye morphogenesis Source: UniProtKB
Epidermal growth factor receptor signaling pathway Source: UniProtKB
Negative regulation of chondrocyte differentiation Source: UniProtKB
Peptidyl-tyrosine phosphorylation Source: UniProtKB
Post-embryonic eye morphogenesis Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Visual perception Source: ProtInc
Cellular Location
Extracellular space; Extracellular matrix. Localizes to the lamina propria underneath the olfactory epithelium.
Involvement in disease
Doyne honeycomb retinal dystrophy (DHRD):
Autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium.
More Infomation

Collantes, E. R. A., Delfin, M. S., Fan, B., Torregosa, J. M. R., Siguan‐Bell, C., Florcruz, N. V. D. G., ... & Wiggs, J. L. (2022). EFEMP1 rare variants cause familial juvenile‐onset open‐angle glaucoma. Human mutation, 43(2), 240-252.

McGrath, E. R., Himali, J. J., Levy, D., Yang, Q., DeCarli, C. S., Courchesne, P., ... & Seshadri, S. (2022). Plasma EFEMP1 is associated with brain aging and dementia: The Framingham Heart Study. Journal of Alzheimer's Disease, (Preprint), 1-10.

Peng, X., Guo, Z., Zhang, Y., Sun, B., & Zhang, Q. (2022). EFEMP1 in direct inguinal hernia: correlation with TIMP3 and regulation toward elastin homoeostasis as well as fibroblast mobility. Journal of Investigative Surgery, 35(1), 203-211.

Garland, D. L., Pierce, E. A., & Fernandez-Godino, R. (2021). Complement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice. Scientific Reports, 11(1), 1-11.

Ying, X., Liu, B., Yuan, Z., Huang, Y., Chen, C., Jiang, X., ... & Ji, W. (2021). METTL1‐m7G‐EGFR/EFEMP1 axis promotes the bladder cancer development. Clinical and translational medicine, 11(12), e675.

Cheng, L., Chen, C., Guo, W., Liu, K., Zhao, Q., Lu, P., ... & Xu, X. (2021). EFEMP1 Overexpression Contributes to Neovascularization in Age-Related Macular Degeneration. Frontiers in Pharmacology, 11, 547436.

Chen, T. J., Chan, T. C., Li, W. S., Li, C. F., Ke, H. L., Wei, Y. C., ... & Li, W. M. (2021). Utility of EFEMP1 in the prediction of oncologic outcomes of urothelial carcinoma. Genes, 12(6), 872.

Driver, S. G., Jackson, M. R., Richter, K., Tomlinson, P., Brockway, B., Halliday, B. J., ... & Wade, E. M. (2020). Biallelic variants in EFEMP1 in a man with a pronounced connective tissue phenotype. European Journal of Human Genetics, 28(4), 445-452.

Wang, Z., Kang, J., Lian, J., Huang, L., Xie, W., Zhao, D., ... & Lin, Z. (2020). EFEMP1 as a potential biomarker for diagnosis and prognosis of osteosarcoma. BioMed research international, 2020.

Cosentino, G., Romero-Cordoba, S., Plantamura, I., Cataldo, A., & Iorio, M. V. (2020). miR-9-mediated inhibition of EFEMP1 contributes to the acquisition of pro-tumoral properties in normal fibroblasts. Cells, 9(9), 2143.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-EFEMP1 Recombinant Antibody (CBXF-0123)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry