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Mouse Anti-EFEMP1 Recombinant Antibody (1D9) (CBMAB-F2762-CQ)

This product is a mouse antibody that recognizes EFEMP1. The antibody 1D9 can be used for immunoassay techniques such as: WB, FC.
See all EFEMP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D9
Antibody Isotype
IgG2a
Application
WB, FC

Basic Information

Immunogen
Full length human recombinant protein of human EFEMP1 (NP_004096)
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
EGF Containing Fibulin Extracellular Matrix Protein 1
Introduction
This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.
Entrez Gene ID
UniProt ID
Alternative Names
EGF Containing Fibulin Extracellular Matrix Protein 1; EGF Containing Fibulin Like Extracellular Matrix Protein 1; EGF-Containing Fibulin-Like Extracellular Matrix Protein 1; Extracellular Protein S1-5; Fibulin-3; FIBL-3; FBLN3; FBNL; Fibrillin-Like Protein;
Research Area
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
Biological Process
Camera-type eye development Source: UniProtKB
Embryonic eye morphogenesis Source: UniProtKB
Epidermal growth factor receptor signaling pathway Source: UniProtKB
Negative regulation of chondrocyte differentiation Source: UniProtKB
Peptidyl-tyrosine phosphorylation Source: UniProtKB
Post-embryonic eye morphogenesis Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Visual perception Source: ProtInc
Cellular Location
Extracellular space; Extracellular matrix. Localizes to the lamina propria underneath the olfactory epithelium.
Involvement in disease
Doyne honeycomb retinal dystrophy (DHRD):
Autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium.

Collantes, E. R. A., Delfin, M. S., Fan, B., Torregosa, J. M. R., Siguan‐Bell, C., Florcruz, N. V. D. G., ... & Wiggs, J. L. (2022). EFEMP1 rare variants cause familial juvenile‐onset open‐angle glaucoma. Human mutation, 43(2), 240-252.

McGrath, E. R., Himali, J. J., Levy, D., Yang, Q., DeCarli, C. S., Courchesne, P., ... & Seshadri, S. (2022). Plasma EFEMP1 is associated with brain aging and dementia: The Framingham Heart Study. Journal of Alzheimer's Disease, (Preprint), 1-10.

Peng, X., Guo, Z., Zhang, Y., Sun, B., & Zhang, Q. (2022). EFEMP1 in direct inguinal hernia: correlation with TIMP3 and regulation toward elastin homoeostasis as well as fibroblast mobility. Journal of Investigative Surgery, 35(1), 203-211.

Garland, D. L., Pierce, E. A., & Fernandez-Godino, R. (2021). Complement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice. Scientific Reports, 11(1), 1-11.

Ying, X., Liu, B., Yuan, Z., Huang, Y., Chen, C., Jiang, X., ... & Ji, W. (2021). METTL1‐m7G‐EGFR/EFEMP1 axis promotes the bladder cancer development. Clinical and translational medicine, 11(12), e675.

Cheng, L., Chen, C., Guo, W., Liu, K., Zhao, Q., Lu, P., ... & Xu, X. (2021). EFEMP1 Overexpression Contributes to Neovascularization in Age-Related Macular Degeneration. Frontiers in Pharmacology, 11, 547436.

Chen, T. J., Chan, T. C., Li, W. S., Li, C. F., Ke, H. L., Wei, Y. C., ... & Li, W. M. (2021). Utility of EFEMP1 in the prediction of oncologic outcomes of urothelial carcinoma. Genes, 12(6), 872.

Driver, S. G., Jackson, M. R., Richter, K., Tomlinson, P., Brockway, B., Halliday, B. J., ... & Wade, E. M. (2020). Biallelic variants in EFEMP1 in a man with a pronounced connective tissue phenotype. European Journal of Human Genetics, 28(4), 445-452.

Wang, Z., Kang, J., Lian, J., Huang, L., Xie, W., Zhao, D., ... & Lin, Z. (2020). EFEMP1 as a potential biomarker for diagnosis and prognosis of osteosarcoma. BioMed research international, 2020.

Cosentino, G., Romero-Cordoba, S., Plantamura, I., Cataldo, A., & Iorio, M. V. (2020). miR-9-mediated inhibition of EFEMP1 contributes to the acquisition of pro-tumoral properties in normal fibroblasts. Cells, 9(9), 2143.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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