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Mouse Anti-EMP3 Recombinant Antibody (3D4) (CBMAB-A2589-LY)

The product is antibody recognizes EMP3. The antibody 3D4 immunoassay techniques such as: WB, ELISA.
See all EMP3 antibodies
Published Data
Fig.1 The expression of EMP3 was examined by immunoblotting.
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Fig.2 The representative IHC staining of EMP3 from normal tissues (I) and different differentiated HCC tumorous (II-IV).
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Fig.3 The IF staining of EMP3 (green color) and DAPI staining of nucleus (blue color) in each cell line.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3D4
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
EMP3 (NP_001416.1, 25 a.a. ~ 68 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
epithelial membrane protein 3
Entrez Gene ID
2014
UniProt ID
P54852
Alternative Names
YMP
Research Area
Probably involved in cell proliferation and cell-cell interactions.
Biological Process
Bleb assembly Source: UniProtKB
Cell death Source: UniProtKB
Cellular Location
Membrane

Chen, Q., Jin, J., Huang, X., Wu, F., Huang, H., & Zhan, R. (2021). EMP3 mediates glioblastoma‐associated macrophage infiltration to drive T cell exclusion. Journal of Experimental & Clinical Cancer Research, 40(1), 1-13.

Kahm, Y. J., Kim, R. K., Jung, U., & Kim, I. G. (2021). Epithelial membrane protein 3 regulates lung cancer stem cells via the TGF‑β signaling pathway. International Journal of Oncology, 59(4), 1-9.

Martija, A. A., & Pusch, S. (2021). The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma. International Journal of Molecular Sciences, 22(10), 5261.

Zhou, K., Sun, Y., Dong, D., Zhao, C., & Wang, W. (2021). EMP3 negatively modulates breast cancer cell DNA replication, DNA damage repair, and stem-like properties. Cell death & disease, 12(9), 1-10.

Li, S., Peng, H., & Li, J. (2020). MiR-765 Regulates Breast Cancer Cell Proliferation, Apoptosis, and Adriamycin Resistance Through Targeting Epithelial Membrane Protein 3. Journal of Biomaterials and Tissue Engineering, 10(8), 1193-1198.

Christians, A., Poisel, E., Hartmann, C., von Deimling, A., & Pusch, S. (2019). Characterization of the epithelial membrane protein 3 interaction network reveals a potential functional link to mitogenic signal transduction regulation. International journal of cancer, 145(2), 461-473.

Ma, Q., Zhang, Y., Liang, H., Zhang, F., Liu, F., Chen, S., ... & Liu, Y. (2018). EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway. Cancer letters, 430, 97-108.

Kusumoto, Y., Okuyama, H., Shibata, T., Konno, K., Takemoto, Y., Maekawa, D., ... & Tomura, M. (2018). Epithelial membrane protein 3 (Emp3) downregulates induction and function of cytotoxic T lymphocytes by macrophages via TNF-α production. Cellular Immunology, 324, 33-41.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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