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Mouse Anti-EMP3 (AA 25-68) Recombinant Antibody (CBFYE-0831) (CBMAB-E1286-FY)

This product is mouse antibody that recognizes EMP3. The antibody CBFYE-0831 can be used for immunoassay techniques such as: ELISA, WB.
See all EMP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0831
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
EMP3 partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: DKSWWTLPGK ESLNLWYDCT WNNDTKTWAC SNVSENGWLK AVQV
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 25-68

Target

Full Name
epithelial membrane protein 3
Introduction
The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
2014
UniProt ID
P54852
Alternative Names
Epithelial Membrane Protein 3; Hematopoietic Neural Membrane Protein 1; HNMP-1; EMP-3; YMP; Protein YMP
Research Area
Probably involved in cell proliferation and cell-cell interactions.
Biological Process
Bleb assembly Source: UniProtKB
Cell death Source: UniProtKB
Cellular Location
Membrane

Chen, Q., Jin, J., Huang, X., Wu, F., Huang, H., & Zhan, R. (2021). EMP3 mediates glioblastoma‐associated macrophage infiltration to drive T cell exclusion. Journal of Experimental & Clinical Cancer Research, 40(1), 1-13.

Kahm, Y. J., Kim, R. K., Jung, U., & Kim, I. G. (2021). Epithelial membrane protein 3 regulates lung cancer stem cells via the TGF‑β signaling pathway. International Journal of Oncology, 59(4), 1-9.

Martija, A. A., & Pusch, S. (2021). The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma. International Journal of Molecular Sciences, 22(10), 5261.

Zhou, K., Sun, Y., Dong, D., Zhao, C., & Wang, W. (2021). EMP3 negatively modulates breast cancer cell DNA replication, DNA damage repair, and stem-like properties. Cell death & disease, 12(9), 1-10.

Li, S., Peng, H., & Li, J. (2020). MiR-765 Regulates Breast Cancer Cell Proliferation, Apoptosis, and Adriamycin Resistance Through Targeting Epithelial Membrane Protein 3. Journal of Biomaterials and Tissue Engineering, 10(8), 1193-1198.

Christians, A., Poisel, E., Hartmann, C., von Deimling, A., & Pusch, S. (2019). Characterization of the epithelial membrane protein 3 interaction network reveals a potential functional link to mitogenic signal transduction regulation. International journal of cancer, 145(2), 461-473.

Ma, Q., Zhang, Y., Liang, H., Zhang, F., Liu, F., Chen, S., ... & Liu, Y. (2018). EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway. Cancer letters, 430, 97-108.

Kusumoto, Y., Okuyama, H., Shibata, T., Konno, K., Takemoto, Y., Maekawa, D., ... & Tomura, M. (2018). Epithelial membrane protein 3 (Emp3) downregulates induction and function of cytotoxic T lymphocytes by macrophages via TNF-α production. Cellular Immunology, 324, 33-41.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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