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Mouse Anti-FANCB Recombinant Antibody (2B10) (CBMAB-A2827-LY)

The product is antibody recognizes FANCB. The antibody 2B10 immunoassay techniques such as: WB, ELISA.
See all FANCB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
FANCB (NP_689846.1, 750 a.a. ~ 858 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fanconi Anemia Complementation Group B
Introduction
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group B. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq]
Entrez Gene ID
2187
UniProt ID
Q8NB91
Alternative Names
FA2; FAAP90; FAAP95; FAB; FACB
Research Area
DNA repair protein required for FANCD2 ubiquitination.
Biological Process
Interstrand cross-link repair Source: InterPro
Negative regulation of double-strand break repair via homologous recombination Source: GO_Central
Positive regulation of double-strand break repair via homologous recombination Source: GO_Central
Replication-born double-strand break repair via sister chromatid exchange Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Fanconi anemia complementation group B (FANCB):
A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Some severe FANCB cases manifest features of VACTERL syndrome with hydrocephalus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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