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Mouse Anti-FANCB Recombinant Antibody (CBXF-2445) (CBMAB-F0053-CQ)

This product is a mouse antibody that recognizes FANCB. The antibody CBXF-2445 can be used for immunoassay techniques such as: WB, ELISA, IHC.
See all FANCB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2445
Antibody Isotype
IgG1, κ
Application
WB, ELISA, IHC

Basic Information

Immunogen
Synthetic peptide- DRRENIHPYR
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fanconi Anemia Complementation Group B
Introduction
This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus.
Entrez Gene ID
2187
UniProt ID
Q8NB91
Alternative Names
Fanconi Anemia Complementation Group B; Fanconi Anemia-Associated Polypeptide Of 95 KDa; FAAP95; Fanconi Anemia Group B Protein; Protein FACB; EC 3.6.3.14;
Research Area
DNA repair protein required for FANCD2 ubiquitination.
Biological Process
Interstrand cross-link repair Source: InterPro
Negative regulation of double-strand break repair via homologous recombination Source: GO_Central
Positive regulation of double-strand break repair via homologous recombination Source: GO_Central
Replication-born double-strand break repair via sister chromatid exchange Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Fanconi anemia complementation group B (FANCB):
A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Some severe FANCB cases manifest features of VACTERL syndrome with hydrocephalus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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