FANCB

This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus. [provided by RefSeq, Apr 2016]
Full Name
Fanconi Anemia Complementation Group B
Research Area
DNA repair protein required for FANCD2 ubiquitination.
Biological Process
Interstrand cross-link repair Source: InterPro
Negative regulation of double-strand break repair via homologous recombination Source: GO_Central
Positive regulation of double-strand break repair via homologous recombination Source: GO_Central
Replication-born double-strand break repair via sister chromatid exchange Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Fanconi anemia complementation group B (FANCB):
A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Some severe FANCB cases manifest features of VACTERL syndrome with hydrocephalus.
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Anti-FANCB antibodies

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Mouse Anti-FANCB Recombinant Antibody (XB0444) (V2LY-0825-LY1361)

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Target: FANCB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: XB0444
Application*: IH
Datasheet SDS

Mouse Anti-FANCB Recombinant Antibody (CBXF-2839) (V2LY-0825-LY1360)

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Target: FANCB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-2839
Application*: E, WB
Datasheet SDS

Mouse Anti-FANCB Recombinant Antibody (CBXF-0282) (V2LY-0825-LY1359)

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Target: FANCB
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXF-0282
Application*: E, WB
Datasheet SDS

Rabbit Anti-FANCB Recombinant Antibody (CBXF-1133) (V2LY-0825-LY1358)

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Target: FANCB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXF-1133
Application*: WB
Datasheet SDS

Mouse Anti-FANCB Recombinant Antibody (CBXF-2445) (V2LY-0825-LY1357)

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Target: FANCB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-2445
Application*: WB, E, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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