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Rabbit Anti-FANCB Recombinant Antibody (CBXF-1133) (CBMAB-F0801-CQ)

This product is a rabbit antibody that recognizes FANCB. The antibody CBXF-1133 can be used for immunoassay techniques such as: WB, IP, IHC-P, FC.
See all FANCB antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1133
Antibody Isotype
IgG
Application
WB, IP, IHC-P, FC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fanconi Anemia Complementation Group B
Introduction
This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus.
Entrez Gene ID
Human2187
Mouse237211
Rat501552
UniProt ID
HumanQ8NB91
MouseQ5XJY6
RatD4A5I2
Alternative Names
Fanconi Anemia Complementation Group B; Fanconi Anemia-Associated Polypeptide Of 95 KDa; FAAP95; Fanconi Anemia Group B Protein; Protein FACB; EC 3.6.3.14;
Research Area
DNA repair protein required for FANCD2 ubiquitination.
Biological Process
Interstrand cross-link repair Source: InterPro
Negative regulation of double-strand break repair via homologous recombination Source: GO_Central
Positive regulation of double-strand break repair via homologous recombination Source: GO_Central
Replication-born double-strand break repair via sister chromatid exchange Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Fanconi anemia complementation group B (FANCB):
A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Some severe FANCB cases manifest features of VACTERL syndrome with hydrocephalus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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