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Mouse Anti-FGF4 (AA 62-123) Recombinant Antibody (2D7D5) (CBMAB-F1704-CQ)

This product is a mouse antibody that recognizes FGF4 (AA 62-123). The antibody 2D7D5 can be used for immunoassay techniques such as: ELISA, FC, WB.
See all FGF4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D7D5
Antibody Isotype
IgG1
Application
ELISA, FC, WB

Basic Information

Immunogen
A region within amino acids 62 and 123 of human FGF4 expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascitic fluid
Preservative
0.03% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 62-123

Target

Full Name
fibroblast growth factor 4
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.
Entrez Gene ID
2249
UniProt ID
P08620
Alternative Names
Fibroblast Growth Factor 4; Transforming Protein KS3; Human Stomach Cancer, Transforming Factor From FGF-Related Oncogene; Heparin Secretory Transforming Protein 1; Heparin-Binding Growth Factor 4; Kaposi Sarcoma Oncogene; HBGF-4; HSTF-1; HSTF1; FGF-4;
Research Area
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
Biological Process
Animal organ morphogenesis Source: GO_Central
Apoptotic process involved in morphogenesis Source: Ensembl
Cartilage condensation Source: Ensembl
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Cellular response to leukemia inhibitory factor Source: Ensembl
Chondroblast differentiation Source: UniProtKB
Cranial suture morphogenesis Source: Ensembl
Embryonic hindlimb morphogenesis Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: MGI
Mesenchymal cell proliferation Source: UniProtKB
Negative regulation of apoptotic process Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of endothelial cell chemotaxis to fibroblast growth factor Source: UniProtKB
Signal transduction Source: ProtInc
Stem cell population maintenance Source: Ensembl
Cellular Location
Secreted

Hongwei, L., Juan, L., Xiaoying, X., & Zhijun, F. (2022). MicroRNA-106b-5p (miR-106b-5p) suppresses the proliferation and metastasis of cervical cancer cells via down-regulating fibroblast growth factor 4 (FGF4) expression. Cytotechnology, 1-10.

Yilmaz, F., Micili, S. C., & Erbil, G. (2022). The role of FGF-4 and FGFR-2 on preimplantation embryo development in experimental maternal diabetes. Gynecological Endocrinology, 38(3), 248-252.

Son, J., Tae, J. Y., Min, S. K., Ko, Y., & Park, J. B. (2020). Fibroblast growth factor-4 maintains cellular viability while enhancing osteogenic differentiation of stem cell spheroids in part by regulating RUNX2 and BGLAP expression. Experimental and Therapeutic Medicine, 20(3), 2013-2020.

Kumagai, Y., Kikuchi, T., Nonaka, A., Hiraide, M., Sato, S., Sakuraoka, M., ... & Kobayashi, M. (2019). Site-directed mutagenesis of cysteine to serine residues affects heparin binding and mitogenicity in fibroblast growth factor 4 produced in Escherichia coli. Biotechnology & Biotechnological Equipment, 33(1), 498-503.

Kim, J., Kim, H. S., Shim, J. J., Lee, J., Kim, A. Y., & Kim, J. (2019). Critical role of the fibroblast growth factor signalling pathway in Ewing's sarcoma octamer‐binding transcription factor 4‐mediated cell proliferation and tumorigenesis. The FEBS Journal, 286(22), 4443-4472.

Chen, D., & Lee, T. H. (2019). New oncogenic signalling pathway: EWS‐Oct4 mediates bone and soft tissue tumourigenesis by activating fibroblast growth factor‐4. The FEBS Journal, 286(22), 4418-4421.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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