FGF4

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.

Full Name

fibroblast growth factor 4

Research Area

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.

Biological Process

Animal organ morphogenesis Source: GO_Central
Apoptotic process involved in morphogenesis Source: Ensembl
Cartilage condensation Source: Ensembl
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Cellular response to leukemia inhibitory factor Source: Ensembl
Chondroblast differentiation Source: UniProtKB
Cranial suture morphogenesis Source: Ensembl
Embryonic hindlimb morphogenesis Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: MGI
Mesenchymal cell proliferation Source: UniProtKB
Negative regulation of apoptotic process Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of endothelial cell chemotaxis to fibroblast growth factor Source: UniProtKB
Signal transduction Source: ProtInc
Stem cell population maintenance Source: Ensembl

Cellular Location

Secreted