Mouse Anti-FGF4 Recombinant Antibody (CBXF-1997) (CBMAB-F1142-CQ)

Name: Mouse Anti-FGF4 Recombinant Antibody (CBXF-1997)
SKU: CBMAB-F1142-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-1997

Application

ELISA, WB

Immunogen

Full length human FGF-4.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium azide

Concentration

0.1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

fibroblast growth factor 4

Introduction

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.

Entrez Gene ID

2249

UniProt ID

P08620

Alternative Names

Fibroblast Growth Factor 4; Transforming Protein KS3; Human Stomach Cancer, Transforming Factor From FGF-Related Oncogene; Heparin Secretory Transforming Protein 1; Heparin-Binding Growth Factor 4; Kaposi Sarcoma Oncogene; HBGF-4; HSTF-1; HSTF1; FGF-4;

Research Area

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.

Biological Process

Animal organ morphogenesis Source: GO_Central
Apoptotic process involved in morphogenesis Source: Ensembl
Cartilage condensation Source: Ensembl
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Cellular response to leukemia inhibitory factor Source: Ensembl
Chondroblast differentiation Source: UniProtKB
Cranial suture morphogenesis Source: Ensembl
Embryonic hindlimb morphogenesis Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: MGI
Mesenchymal cell proliferation Source: UniProtKB
Negative regulation of apoptotic process Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of endothelial cell chemotaxis to fibroblast growth factor Source: UniProtKB
Signal transduction Source: ProtInc
Stem cell population maintenance Source: Ensembl

Cellular Location

Secreted

Hongwei, L., Juan, L., Xiaoying, X., & Zhijun, F. (2022). MicroRNA-106b-5p (miR-106b-5p) suppresses the proliferation and metastasis of cervical cancer cells via down-regulating fibroblast growth factor 4 (FGF4) expression. Cytotechnology, 1-10.

Yilmaz, F., Micili, S. C., & Erbil, G. (2022). The role of FGF-4 and FGFR-2 on preimplantation embryo development in experimental maternal diabetes. Gynecological Endocrinology, 38(3), 248-252.

Son, J., Tae, J. Y., Min, S. K., Ko, Y., & Park, J. B. (2020). Fibroblast growth factor-4 maintains cellular viability while enhancing osteogenic differentiation of stem cell spheroids in part by regulating RUNX2 and BGLAP expression. Experimental and Therapeutic Medicine, 20(3), 2013-2020.

Kumagai, Y., Kikuchi, T., Nonaka, A., Hiraide, M., Sato, S., Sakuraoka, M., ... & Kobayashi, M. (2019). Site-directed mutagenesis of cysteine to serine residues affects heparin binding and mitogenicity in fibroblast growth factor 4 produced in Escherichia coli. Biotechnology & Biotechnological Equipment, 33(1), 498-503.

Kim, J., Kim, H. S., Shim, J. J., Lee, J., Kim, A. Y., & Kim, J. (2019). Critical role of the fibroblast growth factor signalling pathway in Ewing's sarcoma octamer‐binding transcription factor 4‐mediated cell proliferation and tumorigenesis. The FEBS Journal, 286(22), 4443-4472.

Chen, D., & Lee, T. H. (2019). New oncogenic signalling pathway: EWS‐Oct4 mediates bone and soft tissue tumourigenesis by activating fibroblast growth factor‐4. The FEBS Journal, 286(22), 4418-4421.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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