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Mouse Anti-FGF4 Recombinant Antibody (CBT2255) (V2LY-0625-LY12)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2255
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of humanFGF4 (AA: 62-123) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
fibroblast growth factor 4
Entrez Gene ID
2249
UniProt ID
P08620
Research Area
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
Biological Process
Animal organ morphogenesis Source: GO_Central
Apoptotic process involved in morphogenesis Source: Ensembl
Cartilage condensation Source: Ensembl
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Cellular response to leukemia inhibitory factor Source: Ensembl
Chondroblast differentiation Source: UniProtKB
Cranial suture morphogenesis Source: Ensembl
Embryonic hindlimb morphogenesis Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: MGI
Mesenchymal cell proliferation Source: UniProtKB
Negative regulation of apoptotic process Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of endothelial cell chemotaxis to fibroblast growth factor Source: UniProtKB
Signal transduction Source: ProtInc
Stem cell population maintenance Source: Ensembl
Cellular Location
Secreted
More Infomation

Hongwei, L., Juan, L., Xiaoying, X., & Zhijun, F. (2022). MicroRNA-106b-5p (miR-106b-5p) suppresses the proliferation and metastasis of cervical cancer cells via down-regulating fibroblast growth factor 4 (FGF4) expression. Cytotechnology, 1-10.

Yilmaz, F., Micili, S. C., & Erbil, G. (2022). The role of FGF-4 and FGFR-2 on preimplantation embryo development in experimental maternal diabetes. Gynecological Endocrinology, 38(3), 248-252.

Son, J., Tae, J. Y., Min, S. K., Ko, Y., & Park, J. B. (2020). Fibroblast growth factor-4 maintains cellular viability while enhancing osteogenic differentiation of stem cell spheroids in part by regulating RUNX2 and BGLAP expression. Experimental and Therapeutic Medicine, 20(3), 2013-2020.

Kumagai, Y., Kikuchi, T., Nonaka, A., Hiraide, M., Sato, S., Sakuraoka, M., ... & Kobayashi, M. (2019). Site-directed mutagenesis of cysteine to serine residues affects heparin binding and mitogenicity in fibroblast growth factor 4 produced in Escherichia coli. Biotechnology & Biotechnological Equipment, 33(1), 498-503.

Kim, J., Kim, H. S., Shim, J. J., Lee, J., Kim, A. Y., & Kim, J. (2019). Critical role of the fibroblast growth factor signalling pathway in Ewing's sarcoma octamer‐binding transcription factor 4‐mediated cell proliferation and tumorigenesis. The FEBS Journal, 286(22), 4443-4472.

Chen, D., & Lee, T. H. (2019). New oncogenic signalling pathway: EWS‐Oct4 mediates bone and soft tissue tumourigenesis by activating fibroblast growth factor‐4. The FEBS Journal, 286(22), 4418-4421.

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For research use only. Not intended for any clinical use.

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