Sign in or Register   Sign in or Register
  |  

Mouse Anti-FGL1 Recombinant Antibody (CBXF-0645) (CBMAB-F2675-CQ)

This product is a mouse antibody that recognizes FGL1. The antibody CBXF-0645 can be used for immunoassay techniques such as: WB, ICC, IHC-P, ELISA.
See all FGL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0645
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibrinogen Like 1
Introduction
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene.
Entrez Gene ID
2267
UniProt ID
Q08830
Alternative Names
Fibrinogen Like 1; Hepatocyte-Derived Fibrinogen-Related Protein 1; Liver Fibrinogen-Related Protein 1; Hepassocin; LFIRE-1; HFREP1;
Function
Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966).

Responsible for LAG3 T-cell inhibitory function (PubMed:30580966).

Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966).

Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Hepatocyte proliferation Source: UniProtKB
Negative regulation of T cell activation Source: UniProtKB
Regulation of immune response Source: UniProtKB
Cellular Location
Secreted. Secreted in the blood plasma.

Liu, X. H., Qi, L. W., Alolga, R. N., & Liu, Q. (2022). Implication of the hepatokine, fibrinogen-like protein 1 in liver diseases, metabolic disorders and cancer: The need to harness its full potential. International Journal of Biological Sciences, 18(1), 292.

Piórkowska, K., Żukowski, K., Ropka-Molik, K., & Tyra, M. (2022). Variations in Fibrinogen-like 1 (FGL1) Gene Locus as a Genetic Marker Related to Fat Deposition Based on Pig Model and Liver RNA-Seq Data. Genes, 13(8), 1419.

Hua, N., Chen, A., Yang, C., Dong, H., He, X., Ru, G., ... & Wang, S. (2022). The correlation of fibrinogen-like protein-1 expression with the progression and prognosis of hepatocellular carcinoma. Molecular Biology Reports, 49(8), 7911-7919.

Qian, W., Zhao, M., Wang, R., & Li, H. (2021). Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target. Journal of Hematology & Oncology, 14(1), 1-17.

Son, Y., Shin, N. R., Kim, S. H., Park, S. C., & Lee, H. J. (2021). Fibrinogen-like protein 1 modulates sorafenib resistance in human hepatocellular carcinoma cells. International Journal of Molecular Sciences, 22(10), 5330.

Wu, H. T., Chen, S. C., Fan, K. C., Kuo, C. H., Lin, S. Y., Wang, S. H., ... & Li, H. Y. (2020). Targeting fibrinogen‐like protein 1 is a novel therapeutic strategy to combat obesity. The FASEB Journal, 34(2), 2958-2967.

Kang, L., Li, H. Y., Ou, H. Y., Wu, P., Wang, S. H., Chang, C. J., ... & Wu, H. T. (2020). Role of placental fibrinogen-like protein 1 in gestational diabetes. Translational Research, 218, 73-80.

Wang, J., Sanmamed, M. F., Datar, I., Su, T. T., Ji, L., Sun, J., ... & Chen, L. (2019). Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3. Cell, 176(1-2), 334-347.

Zhang, Y., Qiao, H. X., Zhou, Y. T., Hong, L., & Chen, J. H. (2018). Fibrinogen‑like‑protein 1 promotes the invasion and metastasis of gastric cancer and is associated with poor prognosis. Molecular medicine reports, 18(2), 1465-1472.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FGL1 Recombinant Antibody (CBXF-0645)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare