Mouse Anti-FGL1 Recombinant Antibody (CBXF-2999) (CBMAB-F3705-CQ)

Name: Mouse Anti-FGL1 Recombinant Antibody (CBXF-2999)
SKU: CBMAB-F3705-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2999

Application

ELISA, IP, WB

Immunogen

Full length recombinant corresponding to aa19-312 from human FGL1 (AAH07047.1) with GST tag

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fibrinogen Like 1

Introduction

Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene.

Entrez Gene ID

2267

UniProt ID

Q08830

Alternative Names

Fibrinogen Like 1; Hepatocyte-Derived Fibrinogen-Related Protein 1; Liver Fibrinogen-Related Protein 1; Hepassocin; LFIRE-1; HFREP1;

Function

Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966).

Responsible for LAG3 T-cell inhibitory function (PubMed:30580966).

Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966).

Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).

Biological Process

Adaptive immune response Source: UniProtKB-KW
Hepatocyte proliferation Source: UniProtKB
Negative regulation of T cell activation Source: UniProtKB
Regulation of immune response Source: UniProtKB

Cellular Location

Secreted. Secreted in the blood plasma.

Liu, X. H., Qi, L. W., Alolga, R. N., & Liu, Q. (2022). Implication of the hepatokine, fibrinogen-like protein 1 in liver diseases, metabolic disorders and cancer: The need to harness its full potential. International Journal of Biological Sciences, 18(1), 292.

Piórkowska, K., Żukowski, K., Ropka-Molik, K., & Tyra, M. (2022). Variations in Fibrinogen-like 1 (FGL1) Gene Locus as a Genetic Marker Related to Fat Deposition Based on Pig Model and Liver RNA-Seq Data. Genes, 13(8), 1419.

Hua, N., Chen, A., Yang, C., Dong, H., He, X., Ru, G., ... & Wang, S. (2022). The correlation of fibrinogen-like protein-1 expression with the progression and prognosis of hepatocellular carcinoma. Molecular Biology Reports, 49(8), 7911-7919.

Qian, W., Zhao, M., Wang, R., & Li, H. (2021). Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target. Journal of Hematology & Oncology, 14(1), 1-17.

Son, Y., Shin, N. R., Kim, S. H., Park, S. C., & Lee, H. J. (2021). Fibrinogen-like protein 1 modulates sorafenib resistance in human hepatocellular carcinoma cells. International Journal of Molecular Sciences, 22(10), 5330.

Wu, H. T., Chen, S. C., Fan, K. C., Kuo, C. H., Lin, S. Y., Wang, S. H., ... & Li, H. Y. (2020). Targeting fibrinogen‐like protein 1 is a novel therapeutic strategy to combat obesity. The FASEB Journal, 34(2), 2958-2967.

Kang, L., Li, H. Y., Ou, H. Y., Wu, P., Wang, S. H., Chang, C. J., ... & Wu, H. T. (2020). Role of placental fibrinogen-like protein 1 in gestational diabetes. Translational Research, 218, 73-80.

Wang, J., Sanmamed, M. F., Datar, I., Su, T. T., Ji, L., Sun, J., ... & Chen, L. (2019). Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3. Cell, 176(1-2), 334-347.

Zhang, Y., Qiao, H. X., Zhou, Y. T., Hong, L., & Chen, J. H. (2018). Fibrinogen‑like‑protein 1 promotes the invasion and metastasis of gastric cancer and is associated with poor prognosis. Molecular medicine reports, 18(2), 1465-1472.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

FGL1 Matched Antibody Pair (438) (CAT#: APMAB-438LY)

FGL1 Matched Antibody Pair (439) (CAT#: APMAB-439LY)

FGL1 Matched Antibody Pair (440) (CAT#: APMAB-440LY)

FGL1 Matched Antibody Pair (441) (CAT#: APMAB-441LY)

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Mouse Anti-FGL1 Recombinant Antibody (CBXF-0645) (CAT#: CBMAB-F2675-CQ)

FGL1 Matched Antibody Pair (441) (CAT#: APMAB-441LY)

Mouse Anti-FGL1 (AA 19-312) Recombinant Antibody (CBXF-3000) (CAT#: CBMAB-F3706-CQ)

FGL1 Matched Antibody Pair (439) (CAT#: APMAB-439LY)

Mouse Anti-FGL1 Recombinant Antibody (2A4) (CAT#: CBMAB-A2959-LY)

FGL1 Matched Antibody Pair (440) (CAT#: APMAB-440LY)

Mouse Anti-FGL1 Recombinant Antibody (CBXF-0644) (CAT#: CBMAB-F1448-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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