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Mouse Anti-NCOA4 Recombinant Antibody (CBWJN-0392) (CBMAB-N0185-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0392
Antibody Isotype
IgM
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nuclear Receptor Coactivator 4
Introduction
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
Entrez Gene ID
8031
UniProt ID
Q13772
Alternative Names
Nuclear Receptor Coactivator 4; Androgen Receptor-Associated Protein Of 70 KDa; 70 KDa Androgen Receptor Coactivator; RET-Activating Gene ELE1; 70 KDa AR-Activator; NCoA-4; ARA70;
Function
Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.
Biological Process
Cellular iron ion homeostasis Source: Ensembl
Cellular response to estrogen stimulus Source: ARUK-UCL
Cellular response to testosterone stimulus Source: ARUK-UCL
Intracellular estrogen receptor signaling pathway Source: ARUK-UCL
Male gonad development Source: ProtInc
Protein targeting to lysosome Source: MGI
Response to hormone Source: GO_Central
Cellular Location
Lysosome
autolysosome
Nucleus
Involvement in disease
A chromosomal aberration involving NCOA4 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene.
More Infomation

Guggisberg, C. A., Kim, J., Lee, J., Chen, X., & Ryu, M. S. (2022). NCOA4 regulates iron recycling and responds to hepcidin activity and lipopolysaccharide in macrophages. Antioxidants, 11(10), 1926.

Ohshima, T., Yamamoto, H., Sakamaki, Y., Saito, C., & Mizushima, N. (2022). NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy. Journal of Cell Biology, 221(10).

Wang, Z., & Zhang, H. (2022). NCOA4: More than a receptor for ferritinophagy. The Journal of Cell Biology, 221(10).

Mou, Y., Wu, J., Zhang, Y., Abdihamid, O., Duan, C., & Li, B. (2021). Low expression of ferritinophagy-related NCOA4 gene in relation to unfavorable outcome and defective immune cells infiltration in clear cell renal carcinoma. BMC cancer, 21(1), 1-12.

Santana-Codina, N., Gikandi, A., & Mancias, J. D. (2021). The Role of NCOA4-Mediated Ferritinophagy Ferritinophagy in Ferroptosis Ferroptosis. Ferroptosis: Mechanism and Diseases, 41-57.

Zhang, Y., Kong, Y., Ma, Y., Ni, S., Wikerholmen, T., Xi, K., ... & Li, X. (2021). Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines. Oncogene, 40(8), 1425-1439.

Li, W., Li, W., Wang, Y., Leng, Y., & Xia, Z. (2021). Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury. Cell Death Discovery, 7(1), 267.

Fang, Y., Chen, X., Tan, Q., Zhou, H., Xu, J., & Gu, Q. (2021). Inhibiting ferroptosis through disrupting the NCOA4–FTH1 interaction: a new mechanism of action. ACS Central Science, 7(6), 980-989.

Santana-Codina, N., Gableske, S., del Rey, M. Q., Małachowska, B., Jedrychowski, M. P., Biancur, D. E., ... & Mancias, J. D. (2019). NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. Haematologica, 104(7), 1342.

Quiles del Rey, M., & Mancias, J. D. (2019). NCOA4-mediated ferritinophagy: a potential link to neurodegeneration. Frontiers in neuroscience, 13, 238.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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