Mouse Anti-NCOA4 Recombinant Antibody (CBWJN-0391) (CBMAB-N1465-WJ)

Name: Mouse Anti-NCOA4 Recombinant Antibody (CBWJN-0391)
SKU: CBMAB-N1465-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJN-0391

Application

Specificity

Human

Antibody Isotype

IgM

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Nuclear Receptor Coactivator 4

Introduction

This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

Entrez Gene ID

8031

UniProt ID

Q13772

Alternative Names

Nuclear Receptor Coactivator 4; Androgen Receptor-Associated Protein Of 70 KDa; 70 KDa Androgen Receptor Coactivator; RET-Activating Gene ELE1; 70 KDa AR-Activator; NCoA-4; ARA70;

Function

Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.

Biological Process

Cellular iron ion homeostasis Source: Ensembl
Cellular response to estrogen stimulus Source: ARUK-UCL
Cellular response to testosterone stimulus Source: ARUK-UCL
Intracellular estrogen receptor signaling pathway Source: ARUK-UCL
Male gonad development Source: ProtInc
Protein targeting to lysosome Source: MGI
Response to hormone Source: GO_Central

Cellular Location

Lysosome
autolysosome
Nucleus

Involvement in disease

A chromosomal aberration involving NCOA4 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene.

Guggisberg, C. A., Kim, J., Lee, J., Chen, X., & Ryu, M. S. (2022). NCOA4 regulates iron recycling and responds to hepcidin activity and lipopolysaccharide in macrophages. Antioxidants, 11(10), 1926.

Ohshima, T., Yamamoto, H., Sakamaki, Y., Saito, C., & Mizushima, N. (2022). NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy. Journal of Cell Biology, 221(10).

Wang, Z., & Zhang, H. (2022). NCOA4: More than a receptor for ferritinophagy. The Journal of Cell Biology, 221(10).

Mou, Y., Wu, J., Zhang, Y., Abdihamid, O., Duan, C., & Li, B. (2021). Low expression of ferritinophagy-related NCOA4 gene in relation to unfavorable outcome and defective immune cells infiltration in clear cell renal carcinoma. BMC cancer, 21(1), 1-12.

Santana-Codina, N., Gikandi, A., & Mancias, J. D. (2021). The Role of NCOA4-Mediated Ferritinophagy Ferritinophagy in Ferroptosis Ferroptosis. Ferroptosis: Mechanism and Diseases, 41-57.

Zhang, Y., Kong, Y., Ma, Y., Ni, S., Wikerholmen, T., Xi, K., ... & Li, X. (2021). Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines. Oncogene, 40(8), 1425-1439.

Li, W., Li, W., Wang, Y., Leng, Y., & Xia, Z. (2021). Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury. Cell Death Discovery, 7(1), 267.

Fang, Y., Chen, X., Tan, Q., Zhou, H., Xu, J., & Gu, Q. (2021). Inhibiting ferroptosis through disrupting the NCOA4–FTH1 interaction: a new mechanism of action. ACS Central Science, 7(6), 980-989.

Santana-Codina, N., Gableske, S., del Rey, M. Q., Małachowska, B., Jedrychowski, M. P., Biancur, D. E., ... & Mancias, J. D. (2019). NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. Haematologica, 104(7), 1342.

Quiles del Rey, M., & Mancias, J. D. (2019). NCOA4-mediated ferritinophagy: a potential link to neurodegeneration. Frontiers in neuroscience, 13, 238.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

NCOA4 Matched Antibody Pair (778) (CAT#: APMAB-778LY)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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