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NCOA4 Matched Antibody Pair (778) (APMAB-778LY)


See all NCOA4 antibodies
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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-NCOA4 monoclonal, IgG2b antibody, 100 ug
Detection Antibody
Anti-NCOA4 Biotinylated mouse monoclonal, IgG1 antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
Alternative Names
Nuclear Receptor Coactivator 4; Androgen Receptor-Associated Protein Of 70 KDa; 70 KDa Androgen Receptor Coactivator; RET-Activating Gene ELE1; 70 KDa AR-Activator; NCoA-4; ARA70;
Entrez Gene ID
8031
UniProt ID
Q13772
More Infomation

Guggisberg, C. A., Kim, J., Lee, J., Chen, X., & Ryu, M. S. (2022). NCOA4 regulates iron recycling and responds to hepcidin activity and lipopolysaccharide in macrophages. Antioxidants, 11(10), 1926.

Ohshima, T., Yamamoto, H., Sakamaki, Y., Saito, C., & Mizushima, N. (2022). NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy. Journal of Cell Biology, 221(10).

Wang, Z., & Zhang, H. (2022). NCOA4: More than a receptor for ferritinophagy. The Journal of Cell Biology, 221(10).

Mou, Y., Wu, J., Zhang, Y., Abdihamid, O., Duan, C., & Li, B. (2021). Low expression of ferritinophagy-related NCOA4 gene in relation to unfavorable outcome and defective immune cells infiltration in clear cell renal carcinoma. BMC cancer, 21(1), 1-12.

Santana-Codina, N., Gikandi, A., & Mancias, J. D. (2021). The Role of NCOA4-Mediated Ferritinophagy Ferritinophagy in Ferroptosis Ferroptosis. Ferroptosis: Mechanism and Diseases, 41-57.

Zhang, Y., Kong, Y., Ma, Y., Ni, S., Wikerholmen, T., Xi, K., ... & Li, X. (2021). Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines. Oncogene, 40(8), 1425-1439.

Li, W., Li, W., Wang, Y., Leng, Y., & Xia, Z. (2021). Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury. Cell Death Discovery, 7(1), 267.

Fang, Y., Chen, X., Tan, Q., Zhou, H., Xu, J., & Gu, Q. (2021). Inhibiting ferroptosis through disrupting the NCOA4–FTH1 interaction: a new mechanism of action. ACS Central Science, 7(6), 980-989.

Santana-Codina, N., Gableske, S., del Rey, M. Q., Małachowska, B., Jedrychowski, M. P., Biancur, D. E., ... & Mancias, J. D. (2019). NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. Haematologica, 104(7), 1342.

Quiles del Rey, M., & Mancias, J. D. (2019). NCOA4-mediated ferritinophagy: a potential link to neurodegeneration. Frontiers in neuroscience, 13, 238.

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For research use only. Not intended for any clinical use.

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