NCOA4
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
Full Name
Nuclear Receptor Coactivator 4
Function
Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.
Biological Process
Cellular iron ion homeostasis Source: Ensembl
Cellular response to estrogen stimulus Source: ARUK-UCL
Cellular response to testosterone stimulus Source: ARUK-UCL
Intracellular estrogen receptor signaling pathway Source: ARUK-UCL
Male gonad development Source: ProtInc
Protein targeting to lysosome Source: MGI
Response to hormone Source: GO_Central
Cellular response to estrogen stimulus Source: ARUK-UCL
Cellular response to testosterone stimulus Source: ARUK-UCL
Intracellular estrogen receptor signaling pathway Source: ARUK-UCL
Male gonad development Source: ProtInc
Protein targeting to lysosome Source: MGI
Response to hormone Source: GO_Central
Cellular Location
Lysosome
autolysosome
Nucleus
autolysosome
Nucleus
Involvement in disease
A chromosomal aberration involving NCOA4 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene.
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Anti-NCOA4 antibodies
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CompareTarget: NCOA4
Specificity: Human
Target: NCOA4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC-A1012
Application*: E, IF, WB
Target: NCOA4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: C-4
Application*: WB, IP, IF, E
Target: NCOA4
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJN-0391
Application*: WB
Target: NCOA4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2H8
Application*: E, IF, WB
Target: NCOA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F1
Application*: WB
Target: NCOA4
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 1F11
Application*: E, IF, IH, WB
Target: NCOA4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B7
Application*: E, IF, WB
Target: NCOA4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-176063
Application*: E, WB
Target: NCOA4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E5
Application*: E, IH, WB
Target: NCOA4
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJN-0392
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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