NCOA4

This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

Nuclear Receptor Coactivator 4

Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.

Cellular iron ion homeostasis Source: Ensembl
Cellular response to estrogen stimulus Source: ARUK-UCL
Cellular response to testosterone stimulus Source: ARUK-UCL
Intracellular estrogen receptor signaling pathway Source: ARUK-UCL
Male gonad development Source: ProtInc
Protein targeting to lysosome Source: MGI
Response to hormone Source: GO_Central

Lysosome
autolysosome
Nucleus

A chromosomal aberration involving NCOA4 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene.