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Mouse Anti-PCDH15 Recombinant Antibody (CBYC-P204) (CBMAB-P0967-YC)

Provided herein is a Mouse monoclonal antibody against Human Protocadherin Related 15. The antibody can be used for immunoassay techniques, such as ELISA, ICC.
See all PCDH15 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P204
Antibody Isotype
IgG2b
Application
ELISA, ICC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 28-1376

Target

Full Name
Protocadherin Related 15
Introduction
PCDH15 is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur.
Entrez Gene ID
65217
UniProt ID
Q96QU1
Alternative Names
Protocadherin Related 15; Cadherin-Related Family Member 15; USH1F; Deafness, Autosomal Recessive 23; Protocadherin 15; Protocadherin-15; CDHR15; DFNB23;
Function
Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
Biological Process
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
EquilibrioceptionManual Assertion Based On ExperimentIMP:HGNC-UCL
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:InterPro
Inner ear developmentIEA:InterPro
Photoreceptor cell maintenanceManual Assertion Based On ExperimentIMP:HGNC-UCL
Sensory perception of light stimulusManual Assertion Based On ExperimentIMP:HGNC-UCL
Sensory perception of soundManual Assertion Based On ExperimentIMP:HGNC-UCL
Cellular Location
Cell membrane
Efficient localization to the plasma membrane requires the presence of LHFPL5.
Isoform 3
Secreted
Involvement in disease
Usher syndrome 1F (USH1F):
USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.
Usher syndrome 1D/F (USH1DF):
USH1DF patients are heterozygous for mutations in CDH23 and PCDH15, indicating a digenic inheritance pattern.
Deafness, autosomal recessive, 23 (DFNB23):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Extracellular: 27-1376
Helical: 1377-1397
Cytoplasmic: 1398-1955
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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