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Mouse Anti-PTPRF Recombinant Antibody (CBYJL-2333) (CBMAB-L2634-YJ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJL-2333
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Human LAR aa 24-196.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 24-196

Target

Full Name
PTPRF
Introduction
PTPRF is a possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
Entrez Gene ID
Human5792
Mouse19268
Rat360406
UniProt ID
HumanP10586
MouseA2A8L5
RatQ64604
Alternative Names
LAR; BNAH2
Function
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of receptor bindingManual Assertion Based On ExperimentIMP:UniProtKB
Neuron projection regenerationIEA:Ensembl
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of axon regenerationIEA:Ensembl
Synaptic membrane adhesionManual Assertion Based On ExperimentIDA:SynGO
Transmembrane receptor protein tyrosine phosphatase signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Involvement in disease
Aplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2):
A group of congenital deformities encompassing total absence of breasts and nipple (amastia), absence of the nipple (athelia), and absence of the mammary gland (amazia).
Topology
Extracellular: 30-1263
Helical: 1264-1284
Cytoplasmic: 1285-1907
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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