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PTPRF

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance.
Full Name
PTPRF
Function
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of receptor bindingManual Assertion Based On ExperimentIMP:UniProtKB
Neuron projection regenerationIEA:Ensembl
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of axon regenerationIEA:Ensembl
Synaptic membrane adhesionManual Assertion Based On ExperimentIDA:SynGO
Transmembrane receptor protein tyrosine phosphatase signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Involvement in disease
Aplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2):
A group of congenital deformities encompassing total absence of breasts and nipple (amastia), absence of the nipple (athelia), and absence of the mammary gland (amazia).
Topology
Extracellular: 30-1263
Helical: 1264-1284
Cytoplasmic: 1285-1907
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Anti-PTPRF antibodies

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Rabbit Anti-PTPRF Recombinant Antibody (E6W4X) (CBMAB-CP1351-LY)

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Target: PTPRF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E6W4X
Application*: WB, IP, IF (IC)
Datasheet SDS

Rabbit Anti-PTPRF Recombinant Antibody (E9B9S) (CBMAB-CP1350-LY)

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Target: PTPRF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E9B9S
Application*: WB
Datasheet SDS

Rabbit Anti-PTPRF Recombinant Antibody (E8W3H) (CBMAB-CP1349-LY)

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Target: PTPRF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E8W3H
Application*: WB
Datasheet SDS

Mouse Anti-PTPRF Recombinant Antibody (S165-38) (CBMAB-L2635-YJ)

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Target: PTPRF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: S165-38
Application*: WB, IC, IF
Datasheet SDS

Mouse Anti-PTPRF Recombinant Antibody (CBYJL-2333) (CBMAB-L2634-YJ)

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Target: PTPRF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBYJL-2333
Application*: WB
Datasheet SDS

Rat Anti-PTPRF Recombinant Antibody (CBYJL-2332) (CBMAB-L2633-YJ)

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Target: PTPRF
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2332
Application*: WB
Datasheet SDS

Mouse Anti-PTPRF Recombinant Antibody (CBT4302) (V2LY-0625-LY1096)

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Target: PTPRF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4302
Application*: F
Datasheet SDS

Mouse Anti-PTPRF Recombinant Antibody (A1409) (CBMAB-AP11357LY)

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Target: PTPRF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: A1409
Application*: ICC/IF, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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